Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D

D. Tohir; P. E. Wuyung; R. Farida

doi:10.1063/5.0005908

Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D

D. Tohir
, P. E. Wuyung
, R. Farida

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Cytotoxicity of compounds and anticancer potential from Swietenia mahagoni in the ethyl acetate fraction have been analyzed as health or medicinal food. The study was examining cytotoxicity of active fraction from Swietenia mahagoni seed toward breast cancer T47D. Ethyl acetate fraction was fractionated used cromatography coloum with silica gel as the stationary phase and chloroform-ethyl acetate as the mobile phase and yielded 8 fractions. Determination of toxicity of compound has been conducted through Brine Shrimp Lethality Test. Evaluation of chemical compound was performed by phytochemical assay. Results showed that fraction 2 with LC₅₀ 74.30 ppm could inhibit the growth of T47D cell with IC₅₀ of 49.12 ppm. Based on phytochemical assay, fraction 2 consists of alkaloid and steroid/triterpenoid.

Original language	English
Title of host publication	8th International Conference of the Indonesian Chemical Society, ICICS 2019
Editors	Mohamad Rafi, Rudi Heryanto, Wulan Tri Wahyuni
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735420021
DOIs	https://doi.org/10.1063/5.0005908
Publication status	Published - 4 Jun 2020
Event	8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019 - Bogor, Indonesia Duration: 6 Aug 2019 → 7 Aug 2019

Publication series

Name	AIP Conference Proceedings
Volume	2243
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019
Country/Territory	Indonesia
City	Bogor
Period	6/08/19 → 7/08/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1063/5.0005908

Cite this

Tohir, D., Wuyung, P. E., & Farida, R. (2020). Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D. In M. Rafi, R. Heryanto, & W. T. Wahyuni (Eds.), 8th International Conference of the Indonesian Chemical Society, ICICS 2019 Article 020030 (AIP Conference Proceedings; Vol. 2243). American Institute of Physics Inc.. https://doi.org/10.1063/5.0005908

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title = "Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D",

abstract = "Cytotoxicity of compounds and anticancer potential from Swietenia mahagoni in the ethyl acetate fraction have been analyzed as health or medicinal food. The study was examining cytotoxicity of active fraction from Swietenia mahagoni seed toward breast cancer T47D. Ethyl acetate fraction was fractionated used cromatography coloum with silica gel as the stationary phase and chloroform-ethyl acetate as the mobile phase and yielded 8 fractions. Determination of toxicity of compound has been conducted through Brine Shrimp Lethality Test. Evaluation of chemical compound was performed by phytochemical assay. Results showed that fraction 2 with LC50 74.30 ppm could inhibit the growth of T47D cell with IC50 of 49.12 ppm. Based on phytochemical assay, fraction 2 consists of alkaloid and steroid/triterpenoid.",

author = "D. Tohir and Wuyung, \{P. E.\} and R. Farida",

note = "Publisher Copyright: {\textcopyright} 2020 Author(s).; 8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019 ; Conference date: 06-08-2019 Through 07-08-2019",

year = "2020",

month = jun,

day = "4",

doi = "10.1063/5.0005908",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Mohamad Rafi and Rudi Heryanto and Wahyuni, \{Wulan Tri\}",

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Tohir, D, Wuyung, PE & Farida, R 2020, Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D. in M Rafi, R Heryanto & WT Wahyuni (eds), 8th International Conference of the Indonesian Chemical Society, ICICS 2019., 020030, AIP Conference Proceedings, vol. 2243, American Institute of Physics Inc., 8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019, Bogor, Indonesia, 6/08/19. https://doi.org/10.1063/5.0005908

Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D. / Tohir, D.; Wuyung, P. E.; Farida, R.
8th International Conference of the Indonesian Chemical Society, ICICS 2019. ed. / Mohamad Rafi; Rudi Heryanto; Wulan Tri Wahyuni. American Institute of Physics Inc., 2020. 020030 (AIP Conference Proceedings; Vol. 2243).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D

AU - Tohir, D.

AU - Wuyung, P. E.

AU - Farida, R.

PY - 2020/6/4

Y1 - 2020/6/4

N2 - Cytotoxicity of compounds and anticancer potential from Swietenia mahagoni in the ethyl acetate fraction have been analyzed as health or medicinal food. The study was examining cytotoxicity of active fraction from Swietenia mahagoni seed toward breast cancer T47D. Ethyl acetate fraction was fractionated used cromatography coloum with silica gel as the stationary phase and chloroform-ethyl acetate as the mobile phase and yielded 8 fractions. Determination of toxicity of compound has been conducted through Brine Shrimp Lethality Test. Evaluation of chemical compound was performed by phytochemical assay. Results showed that fraction 2 with LC50 74.30 ppm could inhibit the growth of T47D cell with IC50 of 49.12 ppm. Based on phytochemical assay, fraction 2 consists of alkaloid and steroid/triterpenoid.

AB - Cytotoxicity of compounds and anticancer potential from Swietenia mahagoni in the ethyl acetate fraction have been analyzed as health or medicinal food. The study was examining cytotoxicity of active fraction from Swietenia mahagoni seed toward breast cancer T47D. Ethyl acetate fraction was fractionated used cromatography coloum with silica gel as the stationary phase and chloroform-ethyl acetate as the mobile phase and yielded 8 fractions. Determination of toxicity of compound has been conducted through Brine Shrimp Lethality Test. Evaluation of chemical compound was performed by phytochemical assay. Results showed that fraction 2 with LC50 74.30 ppm could inhibit the growth of T47D cell with IC50 of 49.12 ppm. Based on phytochemical assay, fraction 2 consists of alkaloid and steroid/triterpenoid.

UR - https://www.scopus.com/pages/publications/85086668075

U2 - 10.1063/5.0005908

DO - 10.1063/5.0005908

M3 - Conference contribution

AN - SCOPUS:85086668075

T3 - AIP Conference Proceedings

BT - 8th International Conference of the Indonesian Chemical Society, ICICS 2019

A2 - Rafi, Mohamad

A2 - Heryanto, Rudi

A2 - Wahyuni, Wulan Tri

PB - American Institute of Physics Inc.

T2 - 8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019

Y2 - 6 August 2019 through 7 August 2019

ER -

Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D

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