Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cytotoxicity of compounds and anticancer potential from Swietenia mahagoni in the ethyl acetate fraction have been analyzed as health or medicinal food. The study was examining cytotoxicity of active fraction from Swietenia mahagoni seed toward breast cancer T47D. Ethyl acetate fraction was fractionated used cromatography coloum with silica gel as the stationary phase and chloroform-ethyl acetate as the mobile phase and yielded 8 fractions. Determination of toxicity of compound has been conducted through Brine Shrimp Lethality Test. Evaluation of chemical compound was performed by phytochemical assay. Results showed that fraction 2 with LC50 74.30 ppm could inhibit the growth of T47D cell with IC50 of 49.12 ppm. Based on phytochemical assay, fraction 2 consists of alkaloid and steroid/triterpenoid.

Original languageEnglish
Title of host publication8th International Conference of the Indonesian Chemical Society, ICICS 2019
EditorsMohamad Rafi, Rudi Heryanto, Wulan Tri Wahyuni
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420021
DOIs
Publication statusPublished - 4 Jun 2020
Event8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019 - Bogor, Indonesia
Duration: 6 Aug 20197 Aug 2019

Publication series

NameAIP Conference Proceedings
Volume2243
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019
CountryIndonesia
CityBogor
Period6/08/197/08/19

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    Tohir, D., Wuyung, P. E., & Farida, R. (2020). Anti-Cancer activity of Swietenia mahagoni seed extract in ethyl acetate-induced breast cancer cell T47D. In M. Rafi, R. Heryanto, & W. T. Wahyuni (Eds.), 8th International Conference of the Indonesian Chemical Society, ICICS 2019 [020030] (AIP Conference Proceedings; Vol. 2243). American Institute of Physics Inc.. https://doi.org/10.1063/5.0005908