Anti-anemia effect of standardized extract of moringa oleifera lamk. Leaves on aniline induced rats

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Abstract

Background: The leaves of Moringa (Moringa oleifera Lamk.) have been empirically used as anti-anemia for pregnant woman. Objectives: In the present study, the effect of ethanolic extract of moringa leaves was evaluated on the hematology parameters (hemoglobin, red blood cell count, hematocrit), on aniline induced white female rats. Materials and Methods: Thirty female rats strain Sprague-Dawley were divided into six groups: normal, anemia and ferrous fumarate group, and three groups of Moringa leaves extract. All groups, except normal group, induced by aniline at dose 0.005 ml/ g bw intraperitonially. On fifth day, normal and anemia groups were given 0.5% CMC, ferrous fumarate group was given ferrous fumarate orally and three other groups were given Moringa leaves extract at doses 198 mg, 396 mg, and 792 mg/200 g bw until the eleventh day. Results: The results showed that as Moringa leaves extracts increased the level of hemoglobin, red blood cell count, hematocrit, and total iron content in blood. Moreover, Moringa leaves extract at dose 792 mg/200 g bw can improve red blood cell's morphology and increased the level of hemoglobin and red blood cell count significantly (p<0.05). Conclusion: The ethanolic extract of Moringa leaves showed anti-anemia on aniline-induced rats.

Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalPharmacognosy Journal
Volume8
Issue number3
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Anemia
  • Aniline
  • Erythrocyte
  • Moringa oleifera L
  • Total iron

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