TY - GEN
T1 - Annona muricata leaves ethanolic extract in water, n-hexane, and methanol fractions
T2 - 5th International Symposium of Biomedical Engineering, ISBE 2020
AU - Krisanti, Elsa Anisa
AU - Harumanti, Afidya Indina
AU - Mulia, Kamarza
N1 - Funding Information:
This research was funded through the PUTI 2020 proceeding research scheme awarded by Universitas Indonesia. NKB-1077/UN2.RST/HKP.05.00/2020
Publisher Copyright:
© 2021 Author(s).
PY - 2021/3/23
Y1 - 2021/3/23
N2 - Cytotoxicity, antioxidant activity, and a total bioactive assay of the ethanolic extract of Annona muricata leave partitioned into water, n-hexane, and methanol fractions were investigated. The brine shrimp lethality test used for the cytotoxicity assay gave the LC50 values of 84 and 1 ppm for the n-hexane and methanol fractions, respectively. The antioxidant activity determined using DPPH reagent gave IC50 values of 40, 15, and 8 ppm for the n-hexane, water, and methanol fractions, respectively. In addition, the total polyphenol and the total acetogenin content of the methanol fraction were also the highest among the three fractions. These results indicate that the methanol fraction of the Annona muricata has the highest potential as a source for naturally occurring antitumor and antioxidant compounds.
AB - Cytotoxicity, antioxidant activity, and a total bioactive assay of the ethanolic extract of Annona muricata leave partitioned into water, n-hexane, and methanol fractions were investigated. The brine shrimp lethality test used for the cytotoxicity assay gave the LC50 values of 84 and 1 ppm for the n-hexane and methanol fractions, respectively. The antioxidant activity determined using DPPH reagent gave IC50 values of 40, 15, and 8 ppm for the n-hexane, water, and methanol fractions, respectively. In addition, the total polyphenol and the total acetogenin content of the methanol fraction were also the highest among the three fractions. These results indicate that the methanol fraction of the Annona muricata has the highest potential as a source for naturally occurring antitumor and antioxidant compounds.
UR - http://www.scopus.com/inward/record.url?scp=85103479707&partnerID=8YFLogxK
U2 - 10.1063/5.0047484
DO - 10.1063/5.0047484
M3 - Conference contribution
AN - SCOPUS:85103479707
T3 - AIP Conference Proceedings
BT - 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Lischer, Kenny
A2 - Supriadi, Sugeng
A2 - Rahman, Siti Fauziyah
A2 - Whulanza, Yudan
PB - American Institute of Physics Inc.
Y2 - 28 July 2020 through 29 July 2020
ER -