Analysisof CPP-ACP complex in combination with propolis to remineralize enamel

Rizki Amalina, Sri Angky Soekanto, Harun Asjiq Gunawan, Muhamad Sahlan

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10 Citations (Scopus)


The objective of the study was to continuous acid exposure can cause demineralization ofa tooth'senamel surface,creating white spot lesions. These lesions may be remineralized in the right environment. The casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) complex is a known remineralization agent. With the aim of this study was to analyze the ability of the CPP-ACP complex in combination with propolis to remineralize enamel. The methods used was 3 x 5 mm windows on the enamel surface of 12 caries-free human premolars weredemineralized using phosphoric acid 50%. The specimens were divided into four groups: Control, CPP-ACP complex, Propolis, CPP-ACP complex + Propolis 4%. The treatment gels were applied for five minutes, 26 times. The specimens were evaluated for microhardness, surface microstructure and element analysis. As the results showed no statistical differences in microhardness data after the geltreatment groups (p=0.1). The microhardness data between the after-demineralized and after-gel treatment group also showed no differences (p=0.16). An electron micrograph showed that CPP-ACP complex had irregular deposits at the enamel surface and CPP-ACP complex. Propolis 4% showed a homogeneous layer at the enamel surface. Element analysis showed no differences between the groups. It was concluded that a combination of the CPP-ACP complex and propolis might have the potentialto remineralize enamel. The CPP-ACP complex and propolis are promising as an anticariogenic.

Original languageEnglish
Pages (from-to)814-819
Number of pages6
JournalJournal of International Dental and Medical Research
Issue numberSpecialissue
Publication statusPublished - 2017


  • CPP-ACP complex
  • Enamel remineralization
  • Propolis


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