TY - JOUR
T1 - Analysis Protein APOB and TroponinT in Obese Mice (Mus musculus) Induced by Static Magnetic Field as a Marker of Coronary Heart Disease
AU - Sari, Puji
AU - Yunaini, Luluk
AU - Suryandari, Dwi Anita
AU - Oktaviani, Widia Bela
AU - Istiqomah, Rahma Nur
AU - Umiatin,
N1 - Funding Information:
We would like to gratefully acknowledge to Hibah Publikasi Terindeks Intrnasional PUTI grant number NKB-128/UN2.RST/ HKP.05.00/2020, which provide the funding to conduct this research.
Publisher Copyright:
© 2022 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
PY - 2022/9
Y1 - 2022/9
N2 - Obesity is closely related to cardiovascular disease. APOB protein was a better predictor of LDL particle count. Increased troponin T protein is also indicated as an indication of the risk of CHD disease. Static Magnetic Field (SMF) is an electromagnetic applied in therapy because only a simple magnetic disk is used to generate it both in vitro and in vivo. The use of SMF is considered to affect the biological state of cells so that it can affect weight loss in mice. The method used was male c57bl/6j mice with groups of Obes0, Obes2, Obes7, Obes 14, and Obes21 fed high-fat diet and then exposed to SMF with an intensity of 2mT for 1 hour. The results obtained were that there was a significant difference p=0.015 (p<0.05) in the protein concentration of APOB and there was no significant difference in the concentration of cTnT taken from the blood serum of mice. The increase in APOB protein levels in each control group was not found to have an increase in cTnT protein so that the two proteins did not have a linear correlation between the two proteins 0.598 (p>0.05). Most of the protein concentrations of APOB and cTnT decreased in concentration at longer days. It can be seen morphologically in the heart there is a decrease in the number of adipose cells.
AB - Obesity is closely related to cardiovascular disease. APOB protein was a better predictor of LDL particle count. Increased troponin T protein is also indicated as an indication of the risk of CHD disease. Static Magnetic Field (SMF) is an electromagnetic applied in therapy because only a simple magnetic disk is used to generate it both in vitro and in vivo. The use of SMF is considered to affect the biological state of cells so that it can affect weight loss in mice. The method used was male c57bl/6j mice with groups of Obes0, Obes2, Obes7, Obes 14, and Obes21 fed high-fat diet and then exposed to SMF with an intensity of 2mT for 1 hour. The results obtained were that there was a significant difference p=0.015 (p<0.05) in the protein concentration of APOB and there was no significant difference in the concentration of cTnT taken from the blood serum of mice. The increase in APOB protein levels in each control group was not found to have an increase in cTnT protein so that the two proteins did not have a linear correlation between the two proteins 0.598 (p>0.05). Most of the protein concentrations of APOB and cTnT decreased in concentration at longer days. It can be seen morphologically in the heart there is a decrease in the number of adipose cells.
KW - Cardiovaskular
KW - Electromagnetic
KW - Obesity
KW - Protein
UR - http://www.scopus.com/inward/record.url?scp=85142856131&partnerID=8YFLogxK
U2 - 10.5530/pj.2022.14.145
DO - 10.5530/pj.2022.14.145
M3 - Article
AN - SCOPUS:85142856131
SN - 0975-3575
VL - 14
SP - 627
EP - 631
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 5
ER -