Chronic periodontitis is an inflammation of periodontium, result of the host response to bacterial accumulation on the tooth surface, and smoking can alter the host's response to plaque accumulation. Interleukin-12 plays a role in the regulation of the immune response of the host. We aimed to examine the relationship between IL-12 levels in gingival crevicular fluid and chronic periodontitis severity degree in smokers and non-smokers. A cross-sectional study comprising 76 male patients, aged 20-35 years old. Forty-six smokers, and 36 non-smokers. Sixty-four with periodontitis, and 12 healthy subjects. Patients clinically evaluated, and gingival crevicular fluid was retrieved using paper points from which IL-12 levels determined using an enzyme-linked immunosorbent assay. IL-12 levels were higher in patients with chronic periodontitis than in healthy individuals (p=0.042). IL-12 levels in the smoker group were higher than those in the non-smoker group (p=0.012). IL-12 levels were directly proportional to the increase in chronic periodontitis severity degree (p=0.001). As a conclusion, there was a significant relationship between IL-12 levels and chronic periodontitis severity degree. IL-12 levels were higher in patients with chronic periodontitis than in healthy individuals and were also directly proportional to the increase in periodontitis severity degree. IL-12 levels in the smoker group were also higher than those in the non-smoker group.
|Number of pages||5|
|Journal||Journal of International Dental and Medical Research|
|Publication status||Published - 1 Jan 2019|
- Chronic periodontitis
- Gingival crevicular fluid