Analysis of the potential of shale hydrocarbon with geochemical data and seismic interpretation has been successfully done in Jambi Sub-Basin. The parameters in the exploration of shale hydrocarbon contained Total Organic Carbon (TOC) higher than 1%, Index Hydrogen (HI) higher than 100, Vitrinite Reflectance (Ro) higher than 1.3% (for window dry gas), the Net shale Thickness over 75, and Kerogen type classified into type I, II or III. This research area was located in Jambi sub-basin. Jambi sub-basin is a sub-basin of South Sumatra's Basin. Based on the petroleum system in the area of Jambi Sub-Basin, source rocks derived from the form Lahat Formation lacustrine and Talang Akar Formation in the form of terrestrial coal and coal shale. This study aims to identify and analyze the potential of shale hydrocarbons in the Jambi Sub-Basin. Talang Akar Formation is the focus of this study. Talang Akar has a source rock that is ranged from good to excellent and highly potential ranging from 1.5 to 8 wt% TOC in Sub-Basin area Jambi. Seismic inversion is a technique of making the subsurface geological models using seismic data as an input and geological data as control. Analysis shows that TOC values are in the range of 0.5 - 1.5 wt% and Ro is in the range of 0.51 - 1.1%. Petrophysics parameter showed that area having porosity less than 10% and water saturation more than 50%. Seismic interpretation showing that area interest have acoustic impedance more than 7800 (m/s)(g/cc). Based on the Acoustic Impedance distribution map, Northeast and Southeast is an area with good shale hydrocarbon potential.