Analysis of apoptosis and cell proliferation in glioma related to the tumor grade

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Abstract

Introduction: Glioma is a primary brain tumor which arises from glial cells. Up to now, the cure potency of conventional glioma treatments is still low, especially in high-grade glioma. Treatment failure could be caused by cell proliferation and apoptosis inhibition. Regarding that, this research was aimed to analyze the cells proliferation and apoptosis in glioma based on the tumor grade. Methods: This was a cross-sectional study handling 21 glioma tissues which has been categorized into 5 high-grade and 16 low-grade glioma. DNA fragmentation (TUNEL) and cytochrome c analysis were performed to detect apoptosis. Glioma cell proliferation was determined using Proliferating Cell Nuclear Antigen (PCNA) Immunohistochemistry assay. Results: Apoptosis in the high-grade glioma was significantly lower (p<0.05) than that in the low-grade. Moreover, cell proliferation in the high-grade was higher than low-grade glioma, however it was not significant. Conclusion: Apoptosis inhibition was more prominent than the increase of cell proliferation in high-grade glioma. Therefore, novel therapeutic regimen should be developed in order to target cell apoptosis in high-grade glioma.

Original languageEnglish
Pages (from-to)6771-6773
Number of pages3
JournalAdvanced Science Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Apoptosis
  • Brain tumor
  • Cell proliferation
  • Glioma
  • Tumor grade

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