Hypertension is a chronic disease which requires to be controlled with self-management behaviour, such as diet, exercise, medication and stress management. Self-management behaviour (SMB) is the basis for controlling hypertension and preventing complications of hypertension. The purpose of this study was to determine several factors affecting the SMB and to identify the most dominant factor associated with the SMB in patient hypertension in General Hospital 45 Kuningan, West Java. The data were analyzed using chi square and logistic regression tests. The results showed that there were significant relationships between belief in the effectiveness of therapy (p=0.005;OR= 3.48), self-efficacy (p=0.003; OR=3.67), social support (p=0.015; OR=2.87), and communication between health professional and patient (p=0.008; OR=3.27) and the SMB. Communication between health care workers and patients was identified to be the dominant factor affecting the SMB. Therefore, the ability to communicate effectively is a requirement in the nursing care of patients with hypertension.