An efficient one-pot multicomponent synthesis of 1,4-dihydropyridines catalyzed by guanidine hydrochloride

A. H. Cahyana; B. Ardiansah; N. R. Aisy

doi:10.1088/1757-899X/763/1/012048

An efficient one-pot multicomponent synthesis of 1,4-dihydropyridines catalyzed by guanidine hydrochloride

A. H. Cahyana, B. Ardiansah, N. R. Aisy

Department of Chemistry

Research output: Contribution to journal › Conference article › peer-review

4 Citations (Scopus)

Abstract

Guanidine hydrochloride has been successfully used in one-pot three component assembly of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1,4-dihydropyridines. Optimization of reaction conditions revealed that 10 mol% guanidine at room temperature for 4 h in ethanol is the best condition for synthesis of compound 4a in 85 % yield. Furthermore, compound 4b was synthesized and obtained in 62 %.

Original language	English
Article number	012048
Journal	IOP Conference Series: Materials Science and Engineering
Volume	763
Issue number	1
DOIs	https://doi.org/10.1088/1757-899X/763/1/012048
Publication status	Published - 28 Apr 2020
Event	3rd International Symposium on Current Progress in Functional Materials 2018, ISCPFM 2018 - Depok, Indonesia Duration: 8 Aug 2018 → 9 Aug 2018

Keywords

4-dihydropyridine
guanidine HCl
multicomponent

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10.1088/1757-899X/763/1/012048

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title = "An efficient one-pot multicomponent synthesis of 1,4-dihydropyridines catalyzed by guanidine hydrochloride",

abstract = "Guanidine hydrochloride has been successfully used in one-pot three component assembly of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1,4-dihydropyridines. Optimization of reaction conditions revealed that 10 mol% guanidine at room temperature for 4 h in ethanol is the best condition for synthesis of compound 4a in 85 % yield. Furthermore, compound 4b was synthesized and obtained in 62 %.",

keywords = "4-dihydropyridine, guanidine HCl, multicomponent",

author = "Cahyana, {A. H.} and B. Ardiansah and Aisy, {N. R.}",

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T1 - An efficient one-pot multicomponent synthesis of 1,4-dihydropyridines catalyzed by guanidine hydrochloride

AU - Cahyana, A. H.

AU - Ardiansah, B.

AU - Aisy, N. R.

PY - 2020/4/28

Y1 - 2020/4/28

N2 - Guanidine hydrochloride has been successfully used in one-pot three component assembly of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1,4-dihydropyridines. Optimization of reaction conditions revealed that 10 mol% guanidine at room temperature for 4 h in ethanol is the best condition for synthesis of compound 4a in 85 % yield. Furthermore, compound 4b was synthesized and obtained in 62 %.

AB - Guanidine hydrochloride has been successfully used in one-pot three component assembly of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1,4-dihydropyridines. Optimization of reaction conditions revealed that 10 mol% guanidine at room temperature for 4 h in ethanol is the best condition for synthesis of compound 4a in 85 % yield. Furthermore, compound 4b was synthesized and obtained in 62 %.

KW - 4-dihydropyridine

KW - guanidine HCl

KW - multicomponent

UR - http://www.scopus.com/inward/record.url?scp=85084316018&partnerID=8YFLogxK

U2 - 10.1088/1757-899X/763/1/012048

DO - 10.1088/1757-899X/763/1/012048

M3 - Conference article

AN - SCOPUS:85084316018

SN - 1757-8981

VL - 763

JO - IOP Conference Series: Materials Science and Engineering

JF - IOP Conference Series: Materials Science and Engineering

IS - 1

M1 - 012048

T2 - 3rd International Symposium on Current Progress in Functional Materials 2018, ISCPFM 2018

Y2 - 8 August 2018 through 9 August 2018

ER -

An efficient one-pot multicomponent synthesis of 1,4-dihydropyridines catalyzed by guanidine hydrochloride

Abstract

Keywords

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