An efficient one-pot multicomponent synthesis of 1,4-dihydropyridines catalyzed by guanidine hydrochloride

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Guanidine hydrochloride has been successfully used in one-pot three component assembly of aromatic aldehyde, ethyl acetoacetate and ammonium acetate to produce 1,4-dihydropyridines. Optimization of reaction conditions revealed that 10 mol% guanidine at room temperature for 4 h in ethanol is the best condition for synthesis of compound 4a in 85 % yield. Furthermore, compound 4b was synthesized and obtained in 62 %.

Original languageEnglish
Article number012048
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 28 Apr 2020
Event3rd International Symposium on Current Progress in Functional Materials 2018, ISCPFM 2018 - Depok, Indonesia
Duration: 8 Aug 20189 Aug 2018



  • 4-dihydropyridine
  • guanidine HCl
  • multicomponent

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