Amino acid profile in patients of chronic kidney disease on hemodialysis in Indonesia

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Protein energy wasting (PEW) is a nutritional disorder syndrome that occurs 28-80% in chronic kidney disease (CKD) patients on hemodialysis. Hemodialysis cause the nutrients loss including amino acids, increase protein catabolism induced by inflammation, and inhibit protein synthesis. The objective of this study was to acquire the amino acid profile in CKD patients on hemodialysis. This study used cross sectional design and involving 60 subjects of CKD patients aged >18 years on routine hemodialysis at Dr. Cipto Mangunkusumo National Referral Hospital. Amino acids examination was using dried blood spots (DBSs) sample and Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) method. We examined 10 non-essential (alanine, arginine, aspartic acid, glutamic acid, asparagine, glycine, glutamine, proline, serine, tyrosine), 9 essentials (histidine, phenylalanine, isoleucine, leucine, lysine, methionine, threonine, tryptophan, valine), and 2 special (ornithine, citrulline) amino acids. The results showed that almost all amino acids were lower (6 non-essential, 8 essentials, and citrulline), whereas others were higher (aspartate acid, serine) or normal (glutamic acid, glycine, methionine, and ornithine) than normal reference value from Mayo. CKD patients on hemodialysis have decreased amino acid especially essential amino acids. These results can be used in modification of amino acid supplementation CKD patient on hemodialysis in Indonesia.

Original languageEnglish
Title of host publicationInternational Conference on Life Sciences and Technology, ICoLiST 2020
EditorsAhmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Acharee Suksuwan, Chen Siang Ng, Khairunadwa Binti Jemon, Mohamad Amin, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Sunaryono, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440968
DOIs
Publication statusPublished - 25 May 2021
Event3rd International Conference on Life Sciences and Technology, ICoLiST 2020 - Malang, Indonesia
Duration: 29 Sep 2020 → …

Publication series

NameAIP Conference Proceedings
Volume2353
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Life Sciences and Technology, ICoLiST 2020
Country/TerritoryIndonesia
CityMalang
Period29/09/20 → …

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