Altered Resting-State Network in Adolescents with Problematic Internet Use

Kristiana Siste, Jacub Pandelaki, Jun Miyata, Naoya Oishi, Kosuke Tsurumi, Hironobu Fujiwara, Toshiya Murai, Martina Wiwie Nasrun, Tjhin Wiguna, Saptawati Bardosono, Rini Sekartini, Riza Sarasvita, Belinda Julivia Murtani, Lee Thung Sen, Karina Kalani Firdaus

Research output: Contribution to journalArticlepeer-review

Abstract

Problematic internet use (PIU) is increasingly recognized as a mental health concern, particularly among adolescents. The resting-state functional connectivity (rsFC) of the triple-network model has been described inconsistently in PIU. Using resting-state fMRI (rsFMRI) and hypothesizing a lower rsFC between default mode (DMN) and central executive networks (CEN) but a higher rsFC within the salience network (SN), this study scrutinized the neural substrates of PIU adolescents. A total of 30 adolescents with PIU and 30 control subjects underwent rsFMRI. The severity of PIU was evaluated by the Internet Addiction Test. Additionally, personality traits as well as emotional and behavioral problems were evaluated by the Temperament and Character Inventory (TCI) and the Strength and Difficulties Questionnaire (SDQ), respectively. Focusing on the DMN, SN, and CEN, we compared rsFC values between PIU and the control. Subsequently, within the combined group of subjects, TCI and SDQ correlation and mediation effects were investigated. Higher rsFC values of the left lateral prefrontal cortex (LPFC(L)) with the left anterior insula (aIns(L)) were observed for PIU than for the control, while rsFCs of the LPFC(L) with the medial PFC (MPFC), LPFC(L), as well as with the right lateral parietal cortex (LP(R)) were lower for PIU. Among these significant group differences, the rsFC between the LPFC(L) and MPFC was mediated by emotional symptoms (standardized β = −0.12, 95% CI −0.29, −0.0052). The dysfunctional attention switching and incentive salience regulated by the SN were implicated as being a neural correlate of PIU, and this relationship would in part be explained by the emotional dysregulation associated with PIU in adolescents.

Original languageEnglish
Article number5838
JournalJournal of Clinical Medicine
Volume11
Issue number19
DOIs
Publication statusPublished - Oct 2022

Keywords

  • adolescent
  • emotional symptoms
  • functional connectivity
  • internet addiction
  • resting state
  • triple-network model

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