Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

Aulia Arivin Billah; Kukuh Eka Prasetya; Fany Triyatna; Daya Agung Sarwono; Abidin Abidin; Fernanto Rindiyantono; Maiyesni Maiyesni; Miftakul Munir; Indra Saptiama; Rien Ritawidya; Agustino Zulys

doi:10.1515/ract-2023-0234

Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

Aulia Arivin Billah
, Kukuh Eka Prasetya
, Fany Triyatna
, Daya Agung Sarwono
, Abidin Abidin
, Fernanto Rindiyantono
, Maiyesni Maiyesni
, Miftakul Munir
, Indra Saptiama
, Rien Ritawidya
, Agustino Zulys

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The production method of no-carrier added Lutetium-177 (¹⁷⁷Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between ¹⁷⁷Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in ¹⁷⁷Lu yield of 81.19 % and low impurities (¹⁷⁵Yb: 9.28 %, and ¹⁶⁹Yb: 2.09 %). Nevertheless, further study using an enriched ¹⁷⁶Yb target is essential to significantly increase the specific activity of ¹⁷⁷Lu.

Original language	English
Pages (from-to)	175-181
Number of pages	7
Journal	Radiochimica Acta
Volume	112
Issue number	3
DOIs	https://doi.org/10.1515/ract-2023-0234
Publication status	Published - 1 Mar 2024

Keywords

alpha hydroxyisobutyric acid
ion exchange chromatography
no-carrier added Lu
separation method

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10.1515/ract-2023-0234

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Billah, A. A., Prasetya, K. E., Triyatna, F., Sarwono, D. A., Abidin, A., Rindiyantono, F., Maiyesni, M., Munir, M., Saptiama, I., Ritawidya, R., & Zulys, A. (2024). Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium. Radiochimica Acta, 112(3), 175-181. https://doi.org/10.1515/ract-2023-0234

@article{73caa128e3f249ed8dbc2e874129e552,

title = "Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium",

abstract = "The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 \% and low impurities (175Yb: 9.28 \%, and 169Yb: 2.09 \%). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.",

keywords = "alpha hydroxyisobutyric acid, ion exchange chromatography, no-carrier added Lu, separation method",

author = "Billah, \{Aulia Arivin\} and Prasetya, \{Kukuh Eka\} and Fany Triyatna and Sarwono, \{Daya Agung\} and Abidin Abidin and Fernanto Rindiyantono and Maiyesni Maiyesni and Miftakul Munir and Indra Saptiama and Rien Ritawidya and Agustino Zulys",

year = "2024",

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doi = "10.1515/ract-2023-0234",

language = "English",

volume = "112",

pages = "175--181",

journal = "Radiochimica Acta",

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Billah, AA, Prasetya, KE, Triyatna, F, Sarwono, DA, Abidin, A, Rindiyantono, F, Maiyesni, M, Munir, M, Saptiama, I, Ritawidya, R & Zulys, A 2024, 'Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium', Radiochimica Acta, vol. 112, no. 3, pp. 175-181. https://doi.org/10.1515/ract-2023-0234

TY - JOUR

T1 - Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

AU - Billah, Aulia Arivin

AU - Prasetya, Kukuh Eka

AU - Triyatna, Fany

AU - Sarwono, Daya Agung

AU - Abidin, Abidin

AU - Rindiyantono, Fernanto

AU - Maiyesni, Maiyesni

AU - Munir, Miftakul

AU - Saptiama, Indra

AU - Ritawidya, Rien

AU - Zulys, Agustino

PY - 2024/3/1

Y1 - 2024/3/1

N2 - The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.

AB - The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.

KW - alpha hydroxyisobutyric acid

KW - ion exchange chromatography

KW - no-carrier added Lu

KW - separation method

UR - https://www.scopus.com/pages/publications/85186639880

U2 - 10.1515/ract-2023-0234

DO - 10.1515/ract-2023-0234

M3 - Article

AN - SCOPUS:85186639880

SN - 0033-8230

VL - 112

SP - 175

EP - 181

JO - Radiochimica Acta

JF - Radiochimica Acta

IS - 3

ER -

Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

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