Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

Aulia Arivin Billah; Kukuh Eka Prasetya; Fany Triyatna; Daya Agung Sarwono; Abidin Abidin; Fernanto Rindiyantono; Maiyesni Maiyesni; Miftakul Munir; Indra Saptiama; Rien Ritawidya; Agustino Zulys

doi:10.1515/ract-2023-0234

Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

Aulia Arivin Billah, Kukuh Eka Prasetya, Fany Triyatna, Daya Agung Sarwono, Abidin Abidin, Fernanto Rindiyantono, Maiyesni Maiyesni, Miftakul Munir, Indra Saptiama, Rien Ritawidya, Agustino Zulys

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The production method of no-carrier added Lutetium-177 (¹⁷⁷Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between ¹⁷⁷Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in ¹⁷⁷Lu yield of 81.19 % and low impurities (¹⁷⁵Yb: 9.28 %, and ¹⁶⁹Yb: 2.09 %). Nevertheless, further study using an enriched ¹⁷⁶Yb target is essential to significantly increase the specific activity of ¹⁷⁷Lu.

Original language	English
Pages (from-to)	175-181
Number of pages	7
Journal	Radiochimica Acta
Volume	112
Issue number	3
DOIs	https://doi.org/10.1515/ract-2023-0234
Publication status	Published - 1 Mar 2024

Keywords

alpha hydroxyisobutyric acid
ion exchange chromatography
no-carrier added Lu
separation method

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10.1515/ract-2023-0234

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Billah, A. A., Prasetya, K. E., Triyatna, F., Sarwono, D. A., Abidin, A., Rindiyantono, F., Maiyesni, M., Munir, M., Saptiama, I., Ritawidya, R., & Zulys, A. (2024). Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium. Radiochimica Acta, 112(3), 175-181. https://doi.org/10.1515/ract-2023-0234

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title = "Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium",

abstract = "The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.",

keywords = "alpha hydroxyisobutyric acid, ion exchange chromatography, no-carrier added Lu, separation method",

author = "Billah, {Aulia Arivin} and Prasetya, {Kukuh Eka} and Fany Triyatna and Sarwono, {Daya Agung} and Abidin Abidin and Fernanto Rindiyantono and Maiyesni Maiyesni and Miftakul Munir and Indra Saptiama and Rien Ritawidya and Agustino Zulys",

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Billah, AA, Prasetya, KE, Triyatna, F, Sarwono, DA, Abidin, A, Rindiyantono, F, Maiyesni, M, Munir, M, Saptiama, I, Ritawidya, R & Zulys, A 2024, 'Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium', Radiochimica Acta, vol. 112, no. 3, pp. 175-181. https://doi.org/10.1515/ract-2023-0234

TY - JOUR

T1 - Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

AU - Billah, Aulia Arivin

AU - Prasetya, Kukuh Eka

AU - Triyatna, Fany

AU - Sarwono, Daya Agung

AU - Abidin, Abidin

AU - Rindiyantono, Fernanto

AU - Maiyesni, Maiyesni

AU - Munir, Miftakul

AU - Saptiama, Indra

AU - Ritawidya, Rien

AU - Zulys, Agustino

PY - 2024/3/1

Y1 - 2024/3/1

N2 - The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.

AB - The production method of no-carrier added Lutetium-177 (177Lu) was developed from a neutron-activated natural ytterbium (Yb) using column chromatography separation method. Dowex W50 X8 resin and a combination of alpha-hydroxyisobutyric acid (α-HIBA) and hydrochloric acid (HCl) were used as column filler and eluent, respectively. HCl increased the desorption and separation between 177Lu and Yb at a concentration of 0.25 M, while the optimal α-HIBA concentration was 0.15 M, resulting in 177Lu yield of 81.19 % and low impurities (175Yb: 9.28 %, and 169Yb: 2.09 %). Nevertheless, further study using an enriched 176Yb target is essential to significantly increase the specific activity of 177Lu.

KW - alpha hydroxyisobutyric acid

KW - ion exchange chromatography

KW - no-carrier added Lu

KW - separation method

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DO - 10.1515/ract-2023-0234

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VL - 112

SP - 175

EP - 181

JO - Radiochimica Acta

JF - Radiochimica Acta

IS - 3

ER -

Alpha-hydroxyisobutyric acid-assisted solid-liquid chromatography for the separation of lutetium-177 from neutron-irradiated natural ytterbium

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