Alpha-glucosidase inhibiting activity from the most active fraction of calophyllum tomentosum, wight leaves

Berna Elya, Nuraini Puspitasari, Fasya Hadaina Maharani

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The purpose of this study was to obtain the inhibitory concentration, 50% value from the most active fraction of methanolic extract of leaf Calophyllum tomentosum, Wight, and to identify the group of compounds contained in the most active fraction. Methods: The methanol extract was fractionated using the silica gel static phase, the n-hexane motion phase, ethyl acetate, and methanol enhanced by its polarity. Results: There were nine selected fractions tested in inhibitory activity using an enzyme activity inhibitory assay. Conclusions: The results showed the inhibition by the most active fraction is 51.288 μg/mL; this fraction contains of flavonoid, saponin, and terpenoid.

Original languageEnglish
Pages (from-to)73-75
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue numberSpecial Issue October
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • Calophyllum tomentosum wight
  • Diabetes mellitus
  • Enzyme inhibitory assay
  • Fractionation
  • α-glucosidase

Fingerprint Dive into the research topics of 'Alpha-glucosidase inhibiting activity from the most active fraction of calophyllum tomentosum, wight leaves'. Together they form a unique fingerprint.

  • Cite this