TY - JOUR
T1 - Alpha-glucosidase inhibiting activity from the most active fraction of calophyllum tomentosum, wight leaves
AU - Elya, Berna
AU - Puspitasari, Nuraini
AU - Maharani, Fasya Hadaina
N1 - Publisher Copyright:
© 2017, Innovare Academics Sciences Pvt. Ltd. All rights reserved.
PY - 2017/10
Y1 - 2017/10
N2 - Objective: The purpose of this study was to obtain the inhibitory concentration, 50% value from the most active fraction of methanolic extract of leaf Calophyllum tomentosum, Wight, and to identify the group of compounds contained in the most active fraction. Methods: The methanol extract was fractionated using the silica gel static phase, the n-hexane motion phase, ethyl acetate, and methanol enhanced by its polarity. Results: There were nine selected fractions tested in inhibitory activity using an enzyme activity inhibitory assay. Conclusions: The results showed the inhibition by the most active fraction is 51.288 μg/mL; this fraction contains of flavonoid, saponin, and terpenoid.
AB - Objective: The purpose of this study was to obtain the inhibitory concentration, 50% value from the most active fraction of methanolic extract of leaf Calophyllum tomentosum, Wight, and to identify the group of compounds contained in the most active fraction. Methods: The methanol extract was fractionated using the silica gel static phase, the n-hexane motion phase, ethyl acetate, and methanol enhanced by its polarity. Results: There were nine selected fractions tested in inhibitory activity using an enzyme activity inhibitory assay. Conclusions: The results showed the inhibition by the most active fraction is 51.288 μg/mL; this fraction contains of flavonoid, saponin, and terpenoid.
KW - Calophyllum tomentosum wight
KW - Diabetes mellitus
KW - Enzyme inhibitory assay
KW - Fractionation
KW - α-glucosidase
UR - http://www.scopus.com/inward/record.url?scp=85031719231&partnerID=8YFLogxK
U2 - 10.22159/ajpcr.2017.v10s5.23101
DO - 10.22159/ajpcr.2017.v10s5.23101
M3 - Article
AN - SCOPUS:85031719231
SN - 0974-2441
VL - 10
SP - 73
EP - 75
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
IS - Special Issue October
ER -