Alkaline Phosphatase, Bilirubin, and Gama-Glautamyl Transferase Profiles as Supporting Diagnosis in Liver Cirrhosis Based on Aspartate Aminotransferase to Platelet Ratio Index Score

Liver cirrhosis is defined as the end-stage of chronic liver disease, marked by fibrosis and alteration of the liver’s architecture from regular to nodular, and causing alteration of liver function markers. The aspartate aminotransferase (AST) to platelet ratio index (APRI) score has been used as the non-invasive methods to diagnose and classify liver cirrhosis progression. The aim of this study was to assess several profiles of liver function tests namely alkaline phosphatase (ALP), bilirubin, and gamma-glutamyl transferase (GGT) to determine their conditional uses in the classification of liver cirrhosis based on APRI scores. This study used a cross-sectional design with 60 subjects, classified into three stages of APRI scores: <0.5, 0.5 to 2.0, and >2.0. Data were obtained from medical records of dr. Cipto Mangunkusumo National Hospital in 2017. ALP, bilirubin, and GGT profiles were analysed using Kruskal-Wallis. The bilirubin profile showed a significantly higher APRI score of <0.5 and 0.5-2.0 with >2.0 (p<0.05). The GGT profile showed significantly higher in the APRI stage, with scores <0.5 with 0.5-2.0 (p<0.05). There were significant differences in bilirubin and GGT profiles at the stage of liver cirrhosis based on APRI scores; however, this finding did not occur in the ALP profile.