Adverse reactions to a single dose of diethylcarbamazine in patients with Brugia malayi infection in Riau Province, West Indonesia

Inge Sutanto, P. F.L. Boreham, M. Munawar, Purnomo, F. Partono

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A study on the adverse reactions, occurring after treating microfilaremic patients infected with B. malayi, revealed that all reacted to a single oral dose of DEC (5 mg/kg). The major reactions were fever, headache, anorexia, abdominal pain, muscle and joint pains, nausea and vomiting. There seemed to be no association between the time of fever onset and microfilarial density, but the number of cases observed was too small to make any firm conclusion. There was a tendency for more severe reactions to occur in patients with higher microfilaria counts. Local reactions, probably due to destruction of adult worms, were seen in 3 patients. The reactions were serious enough to necessitate the patients spending approximately 48 hours in bed.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Volume16
Issue number3
Publication statusPublished - 1 Dec 1985

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