TY - JOUR
T1 - Advancing towards effective glioma therapy
T2 - MicroRNA derived from umbilical cord mesenchymal stem cells’ extracellular vesicles
AU - Ngadiono, Eko
AU - Hardiany, Novi Silvia
N1 - Funding Information:
The authors thank the Direktorat Riset & Pengabdian Masyarakat Universitas Indonesia (DRPM) for funding the Publikasi Terindeks untuk Tugas Akhir Mahasiswa Universitas Indonesia (PITTA UI 2018).
Publisher Copyright:
© Penerbit Universiti Sains Malaysia, 2019.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas’ ability to develop resistance to chemotherapies. Moreover, glioma stem cells (GSC) contribute to maintaining the glioma population, which benefits from its ability to self-renew and differentiate. Recent research has reported that through the introduction of umbilical cord mesenchymal stem cells (UCMSC) into glioma cells, the growth and development of the glioma cells can be downregulated. It has more currently been found out that UCMSC release extracellular vesicles (EVs) containing miRNA that are responsible for this phenomenon. Therefore, this review analyses literature to discuss all possible miRNAs contained within the UCMSC’s EVs and to elaborate on their molecular mechanisms in halting gliomas and GSC growth. This review will also include the challenges and limitations, to account for which more in vivo research is suggested. In conclusion, this review highlights how miRNAs contained within UCMSC’s EVs are able to downregulate multiple prominent pathways in the survival of gliomas.
AB - A glioma, especially a grade IV glioblastoma, is a malignant tumour with a poor prognosis despite growing medical advancements. Researchers have been looking for better and more effective treatments targeting the molecular pathways of gliomas due to glioblastomas’ ability to develop resistance to chemotherapies. Moreover, glioma stem cells (GSC) contribute to maintaining the glioma population, which benefits from its ability to self-renew and differentiate. Recent research has reported that through the introduction of umbilical cord mesenchymal stem cells (UCMSC) into glioma cells, the growth and development of the glioma cells can be downregulated. It has more currently been found out that UCMSC release extracellular vesicles (EVs) containing miRNA that are responsible for this phenomenon. Therefore, this review analyses literature to discuss all possible miRNAs contained within the UCMSC’s EVs and to elaborate on their molecular mechanisms in halting gliomas and GSC growth. This review will also include the challenges and limitations, to account for which more in vivo research is suggested. In conclusion, this review highlights how miRNAs contained within UCMSC’s EVs are able to downregulate multiple prominent pathways in the survival of gliomas.
KW - Extracellular vesicles
KW - Glioma
KW - Mesenchymal stem cells
KW - MicroRNA
KW - Umbilical cord
UR - http://www.scopus.com/inward/record.url?scp=85073357645&partnerID=8YFLogxK
U2 - 10.21315/mjms2019.26.4.2
DO - 10.21315/mjms2019.26.4.2
M3 - Article
AN - SCOPUS:85073357645
SN - 1394-195X
VL - 26
SP - 5
EP - 16
JO - Malaysian Journal of Medical Sciences
JF - Malaysian Journal of Medical Sciences
IS - 4
ER -