Adult bone marrow stem cells in cartilage therapy.

Andri Maruli Tua Lubis, Vita K. Lubis

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Cartilage defect rarely heals spontaneously since cartilage tissue is poorly vascularized and the lesion usually does not penetrate to subchondral bone, and hence it does not have access to progenitor cells of bone marrow. Severe cartilage damage may lead to osteoarthritis (OA). Current surgical and non-surgical therapeutic interventions in OA are limited to symptom relief and/or repair of focal lesion, and later a total knee replacement is still necessary. Cell therapy with chondrocyte implantation requires healthy cartilage for donor of the cells. Adult mesenchymal stem cells (MSCs) have the ability to differentiate into chondrogenic lineage. They can readily be isolated from bone marrow as well as many other adult tissues and have an extensive proliferation capacity. Therefore, MSCs may offer a great potential to be developed as an alternative for cell-based articular cartilage therapy.

Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalActa medica Indonesiana
Volume44
Issue number1
Publication statusPublished - 1 Jan 2012

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