Admission C-reactive protein, D-dimer, IL-6 and XCL1/lymphotactin levels as predictors of 28-day mortality in COVID-19 patients: a prospective cohort study

Cleopas Martin R.; Adityo Susilo; Herdiman T. Pohan; Iris Rengganis; Alida Roswita Harahap; Aria Kekalih; Dewi Wulandari

doi:10.15562/bmj.v13i1.5069

Admission C-reactive protein, D-dimer, IL-6 and XCL1/lymphotactin levels as predictors of 28-day mortality in COVID-19 patients: a prospective cohort study

Cleopas Martin R., Adityo Susilo, Herdiman T. Pohan, Iris Rengganis, Alida Roswita Harahap, Aria Kekalih, Dewi Wulandari, Suhendro

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Predictors of mortality in COVID-19 patients, which are essential factors in guiding patient management, are poorly understood. In Indonesia, several inflammatory markers have been utilized to evaluate the severity of COVID-19. This study aimed to determine the role of C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), and XCL1/lymphotactin levels in predicting 28-day mortality in patients with COVID-19.

Methods: A prospective cohort study was conducted with COVID-19 patients admitted to the emergency department at Cipto Mangunkusumo Hospital and Medistra Hospital, Jakarta, Indonesia, from June 2020 to February 2021. The predictors of 28-day mortality in COVID-19 patients in this study included CRP, D-dimer, IL-6, and XCL1 levels at admission. Cox proportional hazard regression analysis was used to determine the independent predictors of 28-day mortality in the study population.

Results: A total of 120 patients with COVID-19 were enrolled in the study; 21 (17.5%) died within 28 days after admission. According to our multivariate analysis, a CRP level (HR, 8.55; 95% CI, 3.310-22.088) ≥ 110 mg/L and a D-dimer level (HR, 20.642; 95% CI, 6.909-61.667) ≥ 4640 ng/mL were identified as independent predictors of 28-day mortality in COVID-19 patients.

Conclusion: A C-reactive protein level ≥ 110 mg/L and a D-dimer level ≥ 4640 ng/mL can be used to predict 28-day mortality in COVID-19 patients.

Original language	English
Pages (from-to)	513-518
Journal	Bali Medical Journal
Volume	13
Issue number	1
DOIs	https://doi.org/10.15562/bmj.v13i1.5069
Publication status	Published - 1 Apr 2024

Keywords

C-reactive protein
COVID-19
D-dimer
IL-6
predictor of mortality
XCL1

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10.15562/bmj.v13i1.5069

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title = "Admission C-reactive protein, D-dimer, IL-6 and XCL1/lymphotactin levels as predictors of 28-day mortality in COVID-19 patients: a prospective cohort study",

abstract = "Background: Predictors of mortality in COVID-19 patients, which are essential factors in guiding patient management, are poorly understood. In Indonesia, several inflammatory markers have been utilized to evaluate the severity of COVID-19. This study aimed to determine the role of C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), and XCL1/lymphotactin levels in predicting 28-day mortality in patients with COVID-19.Methods: A prospective cohort study was conducted with COVID-19 patients admitted to the emergency department at Cipto Mangunkusumo Hospital and Medistra Hospital, Jakarta, Indonesia, from June 2020 to February 2021. The predictors of 28-day mortality in COVID-19 patients in this study included CRP, D-dimer, IL-6, and XCL1 levels at admission. Cox proportional hazard regression analysis was used to determine the independent predictors of 28-day mortality in the study population.Results: A total of 120 patients with COVID-19 were enrolled in the study; 21 (17.5%) died within 28 days after admission. According to our multivariate analysis, a CRP level (HR, 8.55; 95% CI, 3.310-22.088) ≥ 110 mg/L and a D-dimer level (HR, 20.642; 95% CI, 6.909-61.667) ≥ 4640 ng/mL were identified as independent predictors of 28-day mortality in COVID-19 patients.Conclusion: A C-reactive protein level ≥ 110 mg/L and a D-dimer level ≥ 4640 ng/mL can be used to predict 28-day mortality in COVID-19 patients.",

keywords = "C-reactive protein, COVID-19, D-dimer, IL-6, predictor of mortality, XCL1",

author = "R., {Cleopas Martin} and Adityo Susilo and Pohan, {Herdiman T.} and Iris Rengganis and Harahap, {Alida Roswita} and Aria Kekalih and Dewi Wulandari and Suhendro",

year = "2024",

month = apr,

day = "1",

doi = "10.15562/bmj.v13i1.5069",

language = "English",

volume = "13",

pages = "513--518",

journal = "Bali Medical Journal",

issn = "2528-6641",

publisher = "Sanglah General Hospital",

number = "1",

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TY - JOUR

T1 - Admission C-reactive protein, D-dimer, IL-6 and XCL1/lymphotactin levels as predictors of 28-day mortality in COVID-19 patients: a prospective cohort study

AU - R., Cleopas Martin

AU - Susilo, Adityo

AU - Pohan, Herdiman T.

AU - Rengganis, Iris

AU - Harahap, Alida Roswita

AU - Kekalih, Aria

AU - Wulandari, Dewi

AU - Suhendro, null

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Background: Predictors of mortality in COVID-19 patients, which are essential factors in guiding patient management, are poorly understood. In Indonesia, several inflammatory markers have been utilized to evaluate the severity of COVID-19. This study aimed to determine the role of C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), and XCL1/lymphotactin levels in predicting 28-day mortality in patients with COVID-19.Methods: A prospective cohort study was conducted with COVID-19 patients admitted to the emergency department at Cipto Mangunkusumo Hospital and Medistra Hospital, Jakarta, Indonesia, from June 2020 to February 2021. The predictors of 28-day mortality in COVID-19 patients in this study included CRP, D-dimer, IL-6, and XCL1 levels at admission. Cox proportional hazard regression analysis was used to determine the independent predictors of 28-day mortality in the study population.Results: A total of 120 patients with COVID-19 were enrolled in the study; 21 (17.5%) died within 28 days after admission. According to our multivariate analysis, a CRP level (HR, 8.55; 95% CI, 3.310-22.088) ≥ 110 mg/L and a D-dimer level (HR, 20.642; 95% CI, 6.909-61.667) ≥ 4640 ng/mL were identified as independent predictors of 28-day mortality in COVID-19 patients.Conclusion: A C-reactive protein level ≥ 110 mg/L and a D-dimer level ≥ 4640 ng/mL can be used to predict 28-day mortality in COVID-19 patients.

AB - Background: Predictors of mortality in COVID-19 patients, which are essential factors in guiding patient management, are poorly understood. In Indonesia, several inflammatory markers have been utilized to evaluate the severity of COVID-19. This study aimed to determine the role of C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), and XCL1/lymphotactin levels in predicting 28-day mortality in patients with COVID-19.Methods: A prospective cohort study was conducted with COVID-19 patients admitted to the emergency department at Cipto Mangunkusumo Hospital and Medistra Hospital, Jakarta, Indonesia, from June 2020 to February 2021. The predictors of 28-day mortality in COVID-19 patients in this study included CRP, D-dimer, IL-6, and XCL1 levels at admission. Cox proportional hazard regression analysis was used to determine the independent predictors of 28-day mortality in the study population.Results: A total of 120 patients with COVID-19 were enrolled in the study; 21 (17.5%) died within 28 days after admission. According to our multivariate analysis, a CRP level (HR, 8.55; 95% CI, 3.310-22.088) ≥ 110 mg/L and a D-dimer level (HR, 20.642; 95% CI, 6.909-61.667) ≥ 4640 ng/mL were identified as independent predictors of 28-day mortality in COVID-19 patients.Conclusion: A C-reactive protein level ≥ 110 mg/L and a D-dimer level ≥ 4640 ng/mL can be used to predict 28-day mortality in COVID-19 patients.

KW - C-reactive protein

KW - COVID-19

KW - D-dimer

KW - IL-6

KW - predictor of mortality

KW - XCL1

UR - https://balimedicaljournal.ejournals.ca/index.php/bmj/article/view/5069

U2 - 10.15562/bmj.v13i1.5069

DO - 10.15562/bmj.v13i1.5069

M3 - Article

SN - 2528-6641

VL - 13

SP - 513

EP - 518

JO - Bali Medical Journal

JF - Bali Medical Journal

IS - 1

ER -

Admission C-reactive protein, D-dimer, IL-6 and XCL1/lymphotactin levels as predictors of 28-day mortality in COVID-19 patients: a prospective cohort study

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