Adipose-derived stem cells and their microenvironment (niche) in type 2 diabetes mellitus

Karina; Jeanne A. Pawitan; Imam Rosadi

doi:10.21037/SCI.2019.12.02

Adipose-derived stem cells and their microenvironment (niche) in type 2 diabetes mellitus

Karina, Jeanne A. Pawitan, Imam Rosadi

Department of Histology Pre Clinic

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction (SVF), which contains adipose tissue stem cells (ASCs), is an alternative therapy that is developed to overcome T2DM. T2DM changes adipose tissue microenvironment (niche) by increasing blood glucose level, oxidative stress and hypoxia, which increase the risk factors of inflammation that leads to remodelling of microenvironment (niche) that may have an impact on various cells in adipose tissue, including ASCs. Therefore, autologous SVF quality might be influenced by diabetes condition through its microenvironment. In this review, we addressed the main function of adipose tissue that includes adipogenesis, microenvironment of ASCs, and SVF in T2DM.

Original language	English
Journal	Stem Cell Investigation
Volume	7
DOIs	https://doi.org/10.21037/SCI.2019.12.02
Publication status	Published - 2020

Keywords

Adipose stem cell
Adipose tissue
Microenvironment
Type-2 diabetes mellitus (T2DM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.21037/SCI.2019.12.02

Cite this

@article{7da3a642711a4188bb99b2fda82ed854,

title = "Adipose-derived stem cells and their microenvironment (niche) in type 2 diabetes mellitus",

abstract = "The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction (SVF), which contains adipose tissue stem cells (ASCs), is an alternative therapy that is developed to overcome T2DM. T2DM changes adipose tissue microenvironment (niche) by increasing blood glucose level, oxidative stress and hypoxia, which increase the risk factors of inflammation that leads to remodelling of microenvironment (niche) that may have an impact on various cells in adipose tissue, including ASCs. Therefore, autologous SVF quality might be influenced by diabetes condition through its microenvironment. In this review, we addressed the main function of adipose tissue that includes adipogenesis, microenvironment of ASCs, and SVF in T2DM.",

keywords = "Adipose stem cell, Adipose tissue, Microenvironment, Type-2 diabetes mellitus (T2DM)",

author = "Karina and Pawitan, {Jeanne A.} and Imam Rosadi",

year = "2020",

doi = "10.21037/SCI.2019.12.02",

language = "English",

volume = "7",

journal = "Stem Cell Investigation",

issn = "2306-9759",

publisher = "AME Publishing Company",

}

TY - JOUR

T1 - Adipose-derived stem cells and their microenvironment (niche) in type 2 diabetes mellitus

AU - Karina,

AU - Pawitan, Jeanne A.

AU - Rosadi, Imam

PY - 2020

Y1 - 2020

N2 - The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction (SVF), which contains adipose tissue stem cells (ASCs), is an alternative therapy that is developed to overcome T2DM. T2DM changes adipose tissue microenvironment (niche) by increasing blood glucose level, oxidative stress and hypoxia, which increase the risk factors of inflammation that leads to remodelling of microenvironment (niche) that may have an impact on various cells in adipose tissue, including ASCs. Therefore, autologous SVF quality might be influenced by diabetes condition through its microenvironment. In this review, we addressed the main function of adipose tissue that includes adipogenesis, microenvironment of ASCs, and SVF in T2DM.

AB - The number of type-2 diabetes mellitus (T2DM) is continuously rising globally. Stromal vascular fraction (SVF), which contains adipose tissue stem cells (ASCs), is an alternative therapy that is developed to overcome T2DM. T2DM changes adipose tissue microenvironment (niche) by increasing blood glucose level, oxidative stress and hypoxia, which increase the risk factors of inflammation that leads to remodelling of microenvironment (niche) that may have an impact on various cells in adipose tissue, including ASCs. Therefore, autologous SVF quality might be influenced by diabetes condition through its microenvironment. In this review, we addressed the main function of adipose tissue that includes adipogenesis, microenvironment of ASCs, and SVF in T2DM.

KW - Adipose stem cell

KW - Adipose tissue

KW - Microenvironment

KW - Type-2 diabetes mellitus (T2DM)

UR - http://www.scopus.com/inward/record.url?scp=85089140566&partnerID=8YFLogxK

U2 - 10.21037/SCI.2019.12.02

DO - 10.21037/SCI.2019.12.02

M3 - Review article

AN - SCOPUS:85089140566

SN - 2306-9759

VL - 7

JO - Stem Cell Investigation

JF - Stem Cell Investigation

ER -

Adipose-derived stem cells and their microenvironment (niche) in type 2 diabetes mellitus

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this