TY - JOUR
T1 - Adherence to treatment and glycemic control in patients with type 2 diabetes mellitus
T2 - A 4-year follow-up ptm bogor cohort study, indonesia
AU - Kaaffah, Silma
AU - Soewondo, Pradana
AU - Riyadina, Woro
AU - Renaldi, Fransiskus Samuel
AU - Sauriasari, Rani
N1 - Funding Information:
The authors are grateful to the Directorate of Research and Community Engagement, Universitas Indonesia, for financial support through PUTI Grant No. NKB-1274/UN2. RST/HKP.05.00/2020. We would like to thank the Health Research and Development Agency, Ministry of Health of the Republic of Indonesia assisted in collection of the PTM Cohort Bogor data subset and the drug compliance data survey in the field and supported this research.We also thank patients at PTM Bogor Cohort Study, Indonesia, for their great contribution to this study.
Publisher Copyright:
© 2021 Kaaffah et al.
PY - 2021
Y1 - 2021
N2 - Purpose: Large-scale evaluation of the treatment adherence in patients with type 2 diabetes mellitus (DM) in Indonesian is limited. We aim to evaluate the treatment adherence of Indonesian type 2 DM patients using national “big data” and investigate its association with glycemic parameters. Patients and Methods: We analyzed baseline and fourth-year data sets from 2011 to 2018 obtained from the Indonesian Ministry of Health Cohort Study of Non-Communicable Disease Risk Factors in Bogor, West Java (the PTM Bogor Cohort Study). This was a retrospective cohort study in which the sample was divided into two groups. One group adhered to treatment from primary health centers and followed the prescribed medicine/ treatment regimen (treated group), while the other did not follow the treatment (untreated group). We evaluated changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) by controlling for other variables. Results: From 5690 subjects, 593 were type 2 DM diagnosed and 342 were eligible at the baseline. At 4-year observation, 212 eligible patients remained, consisting of 62 subjects who adhered to treatment, and more than double that number who were untreated (150 subjects). More significant decreases in FBG and PPBG were found in the treated group (FBG 80.6%, PPBG 90.3%) than in the untreated group (FBG 42.0%, PPBG 67.3%). The results of the multivariate analysis showed that after 4 years observation, treated patients have reduced FBG 3.304 times more and PPBG 3.064 times more than untreated patients, with control factors such as decrease in LDL levels and use of oral drugs. Conclusion: There were less than half as many treated patients as untreated patients involved in the PTM Bogor Study Group. At the fourth-year follow-up, treated patients experienced three times more significant decreases in FBG and PPBG than those who were untreated, even after being controlled by several confounding factors. Given the importance of these findings, it is suggested that immediate strategic action be taken to improve Indonesian patients’ adherence to treatment.
AB - Purpose: Large-scale evaluation of the treatment adherence in patients with type 2 diabetes mellitus (DM) in Indonesian is limited. We aim to evaluate the treatment adherence of Indonesian type 2 DM patients using national “big data” and investigate its association with glycemic parameters. Patients and Methods: We analyzed baseline and fourth-year data sets from 2011 to 2018 obtained from the Indonesian Ministry of Health Cohort Study of Non-Communicable Disease Risk Factors in Bogor, West Java (the PTM Bogor Cohort Study). This was a retrospective cohort study in which the sample was divided into two groups. One group adhered to treatment from primary health centers and followed the prescribed medicine/ treatment regimen (treated group), while the other did not follow the treatment (untreated group). We evaluated changes in fasting blood glucose (FBG) and post-prandial blood glucose (PPBG) by controlling for other variables. Results: From 5690 subjects, 593 were type 2 DM diagnosed and 342 were eligible at the baseline. At 4-year observation, 212 eligible patients remained, consisting of 62 subjects who adhered to treatment, and more than double that number who were untreated (150 subjects). More significant decreases in FBG and PPBG were found in the treated group (FBG 80.6%, PPBG 90.3%) than in the untreated group (FBG 42.0%, PPBG 67.3%). The results of the multivariate analysis showed that after 4 years observation, treated patients have reduced FBG 3.304 times more and PPBG 3.064 times more than untreated patients, with control factors such as decrease in LDL levels and use of oral drugs. Conclusion: There were less than half as many treated patients as untreated patients involved in the PTM Bogor Study Group. At the fourth-year follow-up, treated patients experienced three times more significant decreases in FBG and PPBG than those who were untreated, even after being controlled by several confounding factors. Given the importance of these findings, it is suggested that immediate strategic action be taken to improve Indonesian patients’ adherence to treatment.
KW - Cohort
KW - Diabetes mellitus
KW - Fasting blood glucose
KW - Post-prandial blood glucose
KW - Treatment adherence
UR - http://www.scopus.com/inward/record.url?scp=85118951660&partnerID=8YFLogxK
U2 - 10.2147/PPA.S318790
DO - 10.2147/PPA.S318790
M3 - Article
AN - SCOPUS:85118951660
SN - 1177-889X
VL - 15
SP - 2467
EP - 2477
JO - Patient Preference and Adherence
JF - Patient Preference and Adherence
ER -
