Acromegaly

Acromegaly is a disease that caused by pituitary adenoma. Clinical manifestation that found in patient with acromegaly is caused by tumor mass effect and growth hormone hypersecretion. Acral enlargement, maxillofacial change and headache are commonly seen clinical findings. Diagnoses of acromegaly are based on clinical finding, laboratory evaluation, and imaging. Laboratory evaluation characterized by increased in growth hormone and IGF-I level, while magnetic resonance imaging (MRI) examination of pituitary showed a pituitary adenoma. Mortality in acromegalic patients compared with general population is twofold until fourfold higher. Three approaches to manage acromegaly case are surgery, medical management, and radiotherapy. Treatment that normalizes serum IGF-I and growth hormone (GH) level leads to decrease on mortality rates comparae to those in the normal population.