TY - JOUR
T1 - Achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta thalassemia
T2 - Associated factors and relationship to reduction of spleen enlargement
AU - Atmakusuma, Tubagus Djumhana
AU - Saragih, Edison Yantje Parulian
AU - Rajabto, Wulyo
N1 - Publisher Copyright:
© 2021 Atmakusuma et al. This work is published and licensed by Dove Medical Press Limited.
PY - 2021
Y1 - 2021
N2 - Introduction: The achievement of blood transfusion hemoglobin targets in transfusiondependent beta-thalassemia patients is influenced by several factors such as genotype, hypersplenism, blood compatibility, donor blood adequacy, and transfusion interval. Failure to achieve these targets leads to an increase in the size of the spleen. Meanwhile, the post-transfusion hemoglobin of thalassemia patients that is not regularly evaluated has made it difficult to determine donor adequacy. Therefore, this study aims to determine the proportion of patients who achieve optimal pre-and post-transfusion hemoglobin levels, determine the factors involved, and the relationship between achieving hemoglobin levels with spleen enlargement in adult transfusion-dependent betathalassemia patients. Methods: This retrospective cohort study was conducted using total sampling of adult thalassemia transfusion-dependent patients at Cipto Mangunkusumo Hospital. Data were obtained through medical records. Results: A hundred and ten study subjects fulfilled inclusion criteria. The results showed that the blood transfusion deficit <30 mL/kg/year was associated with achieving pre-and post-transfusion hemoglobin targets (p = 0.008). Furthermore, there were significant differences between the groups that achieved the pre-and post-transfusion target hemoglobin levels on the reduction of spleen enlargement in centimeters (p < 0.001). However, thalassemia genotype, blood compatibility, and transfusion interval did not correlate with the achievement of pre-and post-transfusion hemoglobin. Conclusion: The achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta-thalassemia patients significantly reduced spleen enlargement and contributed to better patient outcomes.
AB - Introduction: The achievement of blood transfusion hemoglobin targets in transfusiondependent beta-thalassemia patients is influenced by several factors such as genotype, hypersplenism, blood compatibility, donor blood adequacy, and transfusion interval. Failure to achieve these targets leads to an increase in the size of the spleen. Meanwhile, the post-transfusion hemoglobin of thalassemia patients that is not regularly evaluated has made it difficult to determine donor adequacy. Therefore, this study aims to determine the proportion of patients who achieve optimal pre-and post-transfusion hemoglobin levels, determine the factors involved, and the relationship between achieving hemoglobin levels with spleen enlargement in adult transfusion-dependent betathalassemia patients. Methods: This retrospective cohort study was conducted using total sampling of adult thalassemia transfusion-dependent patients at Cipto Mangunkusumo Hospital. Data were obtained through medical records. Results: A hundred and ten study subjects fulfilled inclusion criteria. The results showed that the blood transfusion deficit <30 mL/kg/year was associated with achieving pre-and post-transfusion hemoglobin targets (p = 0.008). Furthermore, there were significant differences between the groups that achieved the pre-and post-transfusion target hemoglobin levels on the reduction of spleen enlargement in centimeters (p < 0.001). However, thalassemia genotype, blood compatibility, and transfusion interval did not correlate with the achievement of pre-and post-transfusion hemoglobin. Conclusion: The achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta-thalassemia patients significantly reduced spleen enlargement and contributed to better patient outcomes.
KW - Risk factors
KW - Spleen enlargement
KW - Target hemoglobin level
KW - Transfusion-dependent beta-thalassemia
UR - http://www.scopus.com/inward/record.url?scp=85120785623&partnerID=8YFLogxK
U2 - 10.2147/IJGM.S338114
DO - 10.2147/IJGM.S338114
M3 - Article
AN - SCOPUS:85120785623
SN - 1178-7074
VL - 14
SP - 7515
EP - 7521
JO - International Journal of General Medicine
JF - International Journal of General Medicine
ER -