TY - JOUR
T1 - ACE Inhibitory activity, total phenolic and flavonoid content of watercress (Nasturtium officinale R. Br.) extract
AU - Yaricsha, Catty Amalia
AU - Rissyelly, null
AU - Katrin, null
N1 - Publisher Copyright:
© 2017 Phcog.Net.
PY - 2017
Y1 - 2017
N2 - Introduction: Hypertension is the main risk factor for cardiovascular disease. There are many developed antihypertension drugs, one of them is focusing in ACE (Angiotensin Converting Enzyme) inhibition activity. ACE inhibition activity known can decrease vasoconstriction effect and also can decrease bradykinin degradation (vasodilator) by creating NO (nitric oxide). Methods: In this study, we conducted an in vitro ACE inhibition activity test which was obtained from watercress on 70% ethanolic extract and each fraction (n-hexane, ethyl acetate, and n-butanol). Results: Results of the study showed that ethanolic extract of watercress had ACE activity with IC50 value was 19.05 μg/mL and the highest IC50 of each fraction is ethyl acetate with IC50 value was 2,303 μg/ mL. n-butanol fraction had the highest total phenolic content with 15.798 mg GAE/g of the extract, while the highest total flavonoid content was obtained on ethyl acetate fraction with 82.847 mg QE/g of the extract. Conclusion: The results suggest that Watercress (Nasturtium officinale R. Br.) possess ACE inhibitory activity.
AB - Introduction: Hypertension is the main risk factor for cardiovascular disease. There are many developed antihypertension drugs, one of them is focusing in ACE (Angiotensin Converting Enzyme) inhibition activity. ACE inhibition activity known can decrease vasoconstriction effect and also can decrease bradykinin degradation (vasodilator) by creating NO (nitric oxide). Methods: In this study, we conducted an in vitro ACE inhibition activity test which was obtained from watercress on 70% ethanolic extract and each fraction (n-hexane, ethyl acetate, and n-butanol). Results: Results of the study showed that ethanolic extract of watercress had ACE activity with IC50 value was 19.05 μg/mL and the highest IC50 of each fraction is ethyl acetate with IC50 value was 2,303 μg/ mL. n-butanol fraction had the highest total phenolic content with 15.798 mg GAE/g of the extract, while the highest total flavonoid content was obtained on ethyl acetate fraction with 82.847 mg QE/g of the extract. Conclusion: The results suggest that Watercress (Nasturtium officinale R. Br.) possess ACE inhibitory activity.
KW - Ace inhibitor
KW - Flavonoid
KW - Phenolic
KW - Watercress (nasturtium officinale r. br.)
UR - http://www.scopus.com/inward/record.url?scp=85018485919&partnerID=8YFLogxK
U2 - 10.5530/pj.2017.2.42
DO - 10.5530/pj.2017.2.42
M3 - Article
AN - SCOPUS:85018485919
SN - 0975-3575
VL - 9
SP - 249
EP - 251
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 2
ER -