Acalypha indica and gemfibrozil lowering cholesterol and triglyceride levels in high fructose-cholesterol diet induced rats

Research output: Contribution to journalArticleResearchpeer-review

Abstract

High fructose and cholesterol diets (HFCDs) cause hypercholesterolemia, hypertriglyceridemia, and many acute and chronic serious diseases. Current established treatments, such as simvastatin (SIM) and gemfibrozil (GEM), have been successful in lowering cholesterol and triglyceride levels, but their long-term use poses a risk for organ dysfunction. Herbal medicine addition to this treatment can improve patient outcomes. This study examined the effects of Acalypha indica L. (AI) root extract in improving the efficacy of SIM and GEM treatment and attempted to reduce their side effects. Five of the seven male Sprague-Dawley rat groups were maintained daily on HFCD for 4 weeks while being treated with either SIM, GEM, AI, SIM+AI, or GEM+AI. The remaining two groups were given only HFCD and normal diet, respectively. Liver HMG-CoA reductase and PPAR-α, blood total cholesterol and triglyceride levels, and liver histopathology were measured after a 1-month therapy. The SIM+AI group had low HMG-CoA reductase levels, whereas the GEM+AI group had high PPAR-α levels. The GEM+AI group showed normal liver histopathology, whereas the SIM+AI and HFCD-only groups showed similar features. Adding AI to SIM and GEM lowered triglyceride levels. GEM+AI significantly lowered cholesterol levels, indicating that AI functions synergistically as a PPAR-α agonist.

Original languageEnglish
Pages (from-to)809-812
Number of pages4
JournalJournal of International Dental and Medical Research
Volume12
Issue number2
Publication statusPublished - 1 Jan 2019

Fingerprint

Gemfibrozil
Fructose
Triglycerides
Simvastatin
Cholesterol
Diet
Peroxisome Proliferator-Activated Receptors
Hydroxymethylglutaryl CoA Reductases
Liver
Acalypha
Herbal Medicine
Hypertriglyceridemia
Therapeutics
Hypercholesterolemia
Sprague Dawley Rats
Chronic Disease

Keywords

  • Acalypha indica
  • Gemfibrozil
  • HFCD
  • HMG-CoA reductase
  • PPAR-α

Cite this

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title = "Acalypha indica and gemfibrozil lowering cholesterol and triglyceride levels in high fructose-cholesterol diet induced rats",
abstract = "High fructose and cholesterol diets (HFCDs) cause hypercholesterolemia, hypertriglyceridemia, and many acute and chronic serious diseases. Current established treatments, such as simvastatin (SIM) and gemfibrozil (GEM), have been successful in lowering cholesterol and triglyceride levels, but their long-term use poses a risk for organ dysfunction. Herbal medicine addition to this treatment can improve patient outcomes. This study examined the effects of Acalypha indica L. (AI) root extract in improving the efficacy of SIM and GEM treatment and attempted to reduce their side effects. Five of the seven male Sprague-Dawley rat groups were maintained daily on HFCD for 4 weeks while being treated with either SIM, GEM, AI, SIM+AI, or GEM+AI. The remaining two groups were given only HFCD and normal diet, respectively. Liver HMG-CoA reductase and PPAR-α, blood total cholesterol and triglyceride levels, and liver histopathology were measured after a 1-month therapy. The SIM+AI group had low HMG-CoA reductase levels, whereas the GEM+AI group had high PPAR-α levels. The GEM+AI group showed normal liver histopathology, whereas the SIM+AI and HFCD-only groups showed similar features. Adding AI to SIM and GEM lowered triglyceride levels. GEM+AI significantly lowered cholesterol levels, indicating that AI functions synergistically as a PPAR-α agonist.",
keywords = "Acalypha indica, Gemfibrozil, HFCD, HMG-CoA reductase, PPAR-α",
author = "Adisti Dwijayanti and Hakim, {Rani Wardani} and Krisnamurt, {Desak Gede Budi} and Siti Farida and Prijanti, {Ani Retno} and Dewi Sukmawati and Purwaningsih, {Erni Hernawati}",
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T1 - Acalypha indica and gemfibrozil lowering cholesterol and triglyceride levels in high fructose-cholesterol diet induced rats

AU - Dwijayanti, Adisti

AU - Hakim, Rani Wardani

AU - Krisnamurt, Desak Gede Budi

AU - Farida, Siti

AU - Prijanti, Ani Retno

AU - Sukmawati, Dewi

AU - Purwaningsih, Erni Hernawati

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