Abstract #1022296: Association between Laboratory Parameters on Admission and Poor Clinical Outcome of COVID-19 in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Objective
This study aims to assess the association between laboratory parameters on admission and poor clinical outcome i.e. intensive care admission, and mortality of COVID-19 in-patients presented with T2DM in a tertiary hospital.
Methods
This is a cross-sectional study conducted in Fatmawati General Hospital, Jakarta, Indonesia, recruiting COVID-19 adult patients hospitalized during the period March to November 2020. Using the medical records data, we collected random blood glucose (RBG), C-reactive protein (CRP), ferritin, D-dimer, lactate dehydrogenase (LDH), neutrophil to lymphocyte (NLR), and monocyte to lymphocyte ratio (MLR) levels upon admission. Poor clinical outcomes defined as intensive care unit admission and in-hospital mortality. T-test or Mann-Whitney u-test were used to assess the association between variables where applicable.
Results
Of the 506 patients admitted to our hospital, 144 (28.46%) patients had diabetes. Intensive care admission documented in 297 (58.70%) patients with a higher proportion in within diabetes compared to non-diabetes group (86.11% vs. 47.79%) and mortality documented in 140 (27.67%) patients (45.14% in diabetes and 20.72% in non-diabetes groups). Compared to their counterparts, subjects with diabetes had higher RBG, CRP, Ferritin, D-dimer, and LDH levels (p< 0.05). Of patients admitted to intensive care , subjects with diabetes had higher d-dimer, MLR, and RBGs levels than non-diabetes subjects (p< 0.05). However, we observed no difference between diabetes and non-diabetes subjects in mortality in regards to their laboratory parameters (p >0.05) excepts for RBG level (p< 0.001).
Discussion/Conclusion
Diabetes increased the risk of poor outcome in COVID-19 due to a higher inflammatory state documented by laboratory examinations on admission.