TY - GEN
T1 - Abrine (N-methyltryptophan), an alkaloid from Abrus precatorius Linn. leaves extract
AU - Agustina, R.
AU - Cahyana, A. H.
AU - Tjandrawinata, R. R.
N1 - Funding Information:
The Authors would like to acknowledge the facility and knowledge support from PT Dexa Medica – DLBS, especially to Dr. rer. nat. James Sinambela and Ujiatmi Dwi Marlupi, M.Si. This research was supported by PT Dexa Medica with grant number 128/IMC/DLBS/2018.
Publisher Copyright:
© 2020 Author(s).
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Abrus precatorius Linn. (Fabaceae), also known as "Saga Rambat", is commonly found in tropical countries, including Indonesia. The leaves of the plant are widely used commercially in Indonesia to treat cough and sprue. The aim of this research is to segregate and identify the chemical compound of A. precatorius leaf methanolic extract originated from Kebumen, Central Java, Indonesia. Dried leaves of A. precatorius were extracted with methanol then partitioned between n-hexane/water, methylene chloride/water, and ethyl acetate/water. The fractionation of the water layer was performed by various stationary phases. Identification of the chemical structure was performed by using data combination of 1D-NMR (1H-NMR and 13C-NMR), infra-red (IR), and mass spectrum (MS). Purification of water fraction from methanolic extract of A. precatorius leaves resulted in isolation of an alkaloid, identified as abrine or N-methyltryptophan. The isolated compound was also identified in five other origins of the plant in Java Island, Indonesia.
AB - Abrus precatorius Linn. (Fabaceae), also known as "Saga Rambat", is commonly found in tropical countries, including Indonesia. The leaves of the plant are widely used commercially in Indonesia to treat cough and sprue. The aim of this research is to segregate and identify the chemical compound of A. precatorius leaf methanolic extract originated from Kebumen, Central Java, Indonesia. Dried leaves of A. precatorius were extracted with methanol then partitioned between n-hexane/water, methylene chloride/water, and ethyl acetate/water. The fractionation of the water layer was performed by various stationary phases. Identification of the chemical structure was performed by using data combination of 1D-NMR (1H-NMR and 13C-NMR), infra-red (IR), and mass spectrum (MS). Purification of water fraction from methanolic extract of A. precatorius leaves resulted in isolation of an alkaloid, identified as abrine or N-methyltryptophan. The isolated compound was also identified in five other origins of the plant in Java Island, Indonesia.
KW - abrine
KW - Abrus precatorius leaves
KW - methanolic extract
KW - N-methyltryptophan
UR - http://www.scopus.com/inward/record.url?scp=85086657625&partnerID=8YFLogxK
U2 - 10.1063/5.0007888
DO - 10.1063/5.0007888
M3 - Conference contribution
AN - SCOPUS:85086657625
T3 - AIP Conference Proceedings
BT - Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
A2 - Mart, Terry
A2 - Triyono, Djoko
A2 - Ivandini, Tribidasari Anggraningrum
PB - American Institute of Physics Inc.
T2 - 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
Y2 - 9 July 2019 through 10 July 2019
ER -