Abrine (N-methyltryptophan), an alkaloid from Abrus precatorius Linn. leaves extract

R. Agustina, A. H. Cahyana, R. R. Tjandrawinata

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Abrus precatorius Linn. (Fabaceae), also known as "Saga Rambat", is commonly found in tropical countries, including Indonesia. The leaves of the plant are widely used commercially in Indonesia to treat cough and sprue. The aim of this research is to segregate and identify the chemical compound of A. precatorius leaf methanolic extract originated from Kebumen, Central Java, Indonesia. Dried leaves of A. precatorius were extracted with methanol then partitioned between n-hexane/water, methylene chloride/water, and ethyl acetate/water. The fractionation of the water layer was performed by various stationary phases. Identification of the chemical structure was performed by using data combination of 1D-NMR (1H-NMR and 13C-NMR), infra-red (IR), and mass spectrum (MS). Purification of water fraction from methanolic extract of A. precatorius leaves resulted in isolation of an alkaloid, identified as abrine or N-methyltryptophan. The isolated compound was also identified in five other origins of the plant in Java Island, Indonesia.

Original languageEnglish
Title of host publicationProceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
EditorsTerry Mart, Djoko Triyono, Tribidasari Anggraningrum Ivandini
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420014
DOIs
Publication statusPublished - 1 Jun 2020
Event5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 - Depok, Indonesia
Duration: 9 Jul 201910 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2242
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
CountryIndonesia
CityDepok
Period9/07/1910/07/19

Keywords

  • abrine
  • Abrus precatorius leaves
  • methanolic extract
  • N-methyltryptophan

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