A with-in host Dengue infection model with immune response

Nuning Nuraini, Hengki Tasman, Edy Soewono, Kuntjoro Adji Sidarto

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


A model of viral infection of monocytes population by Dengue virus is formulated here. The model can capture phenomena that dengue virus is quickly cleared in approximately 7 days after the onset of the symptoms. The model takes into account the immune response. It is shown that the quantity of free virus is decreasing when the viral invasion rate is increasing. The basic reproduction ratio of model without immune response is reduced significantly by adding the immune response. Numerical simulations indicate that the growth of immune response and the invasion rate are very crucial in identification of the intensity of infection.

Original languageEnglish
Pages (from-to)1148-1155
Number of pages8
JournalMathematical and Computer Modelling
Issue number5-6
Publication statusPublished - Mar 2009


  • Basic reproduction ratio
  • Bifurcation diagram
  • Dengue viral infection
  • With-in host model


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