A review of macrodystrophia lipomatosa: Revisitation

Theddeus O.H. Prasetyono, Enjeline Hanafi, Windi Astriana

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

Macrodystrophia lipomatosa (MDL) is a rare congenital non-hereditary disorder that has significant impact on patient morbidity. This study provides a comprehensive review of the natural history, diagnosis, management, and outcomes of the disorder. A literature search in PubMed was conducted to identify cases of MDL from January 1950 to 14 February 2014. After ruling out articles without information related to the management of the disorder, a summary of 32 studies was performed. An additional three cases from the authors are also presented. Based on 57 journal articles and three additional cases from the authors, around 108 cases of MDL were reviewed. Most patients were males who were admitted to a treatment clinic in the first four years of life. The lower extremities were more frequently affected, with unilateral presentation being most common. They commonly underwent a single-staged surgical procedure with follow-up periods ranging from more than one year up to 21 years. Out of 43 cases that underwent surgical procedures, 13 reported no complications, and there were seven cases of esthetic satisfaction and 15 cases of significant functional improvement. Depending on the severity of a patient’s condition, the use of non-invasive diagnostic tools should be carefully considered. Surgery might be a better choice of management than observation, taking into account possible future complications in the absence of surgery and the beneficial outcomes of surgical procedures.

Original languageEnglish
Pages (from-to)391-406
Number of pages16
JournalArchives of Plastic Surgery
Volume42
Issue number4
DOIs
Publication statusPublished - 1 Jul 2015

Keywords

  • Congenital limb deformities
  • Fingers
  • Lower extremity
  • Upper extremity

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