TY - JOUR
T1 - A randomized control trial of platelet-rich plasma in supporting the recovery of postpartum levator ani muscle trauma
AU - Moegni, Fernandi
AU - Rachman, Andhika
AU - Ilyas, Ermita Ibrahim
AU - Harahap, Alida
AU - Irianta, Trika
AU - Hidayat, Ferry
AU - Ocviyanti, Dwiana
AU - Santoso, Budi Iman
N1 - Funding Information:
The authors would like to thank Hayandra Lab for their assistance in developing and providing PRP manufacturing kits. The completion of this study was achieved by their support and cooperation.
Publisher Copyright:
© 2022 Authors.
PY - 2022/9
Y1 - 2022/9
N2 - BACKGROUND Pelvic floor dysfunction (PFD) is mostly caused by childbirth levator ani muscle (LAM) trauma. We hypothesized that platelet-rich plasma (PRP) therapy could support the recovery of LAM in postpartum trauma. METHODS A prospective, single-blind, randomized control study was enrolled in primigravid women from November 2016 to July 2019 at 21 health facilities in Jakarta, Indonesia. Subjects were injected with autologous PRP or placebo at LAM during perineorrhaphy after childbirth. The primary outcome was regaining LAM strength and reducing levator hiatal area at 3 months postpartum. The LAM strength was examined by perineometer (cmH₂O), and levator hiatal area was examined by transperineal ultrasound (cm²) at antenatal and 3 months after delivery. Mann–Whitney U test and Wilcoxon signed-rank test were used for analysis. The study was registered in clinicaltrials.gov: NCT03021954. RESULTS Among 240 women, 58 were eligible for analysis. There were no differences in LAM strength and levator ani hiatal area at 3 months postpartum between the two groups (p = 0.583 and p = 0.185, respectively). CONCLUSIONS PRP therapy did not show a difference in the muscle recovery healing process.
AB - BACKGROUND Pelvic floor dysfunction (PFD) is mostly caused by childbirth levator ani muscle (LAM) trauma. We hypothesized that platelet-rich plasma (PRP) therapy could support the recovery of LAM in postpartum trauma. METHODS A prospective, single-blind, randomized control study was enrolled in primigravid women from November 2016 to July 2019 at 21 health facilities in Jakarta, Indonesia. Subjects were injected with autologous PRP or placebo at LAM during perineorrhaphy after childbirth. The primary outcome was regaining LAM strength and reducing levator hiatal area at 3 months postpartum. The LAM strength was examined by perineometer (cmH₂O), and levator hiatal area was examined by transperineal ultrasound (cm²) at antenatal and 3 months after delivery. Mann–Whitney U test and Wilcoxon signed-rank test were used for analysis. The study was registered in clinicaltrials.gov: NCT03021954. RESULTS Among 240 women, 58 were eligible for analysis. There were no differences in LAM strength and levator ani hiatal area at 3 months postpartum between the two groups (p = 0.583 and p = 0.185, respectively). CONCLUSIONS PRP therapy did not show a difference in the muscle recovery healing process.
KW - obstetric labor complication
KW - parturition
KW - pelvic floor disorder
KW - platelet-rich plasma
KW - randomized controlled trial
UR - http://www.scopus.com/inward/record.url?scp=85144543907&partnerID=8YFLogxK
U2 - 10.13181/mji.oa.226115
DO - 10.13181/mji.oa.226115
M3 - Article
AN - SCOPUS:85144543907
SN - 0853-1773
VL - 31
SP - 186
EP - 192
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
IS - 3
ER -