A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007

Tetsuo Arakawa; Yasuhiro Fujiwara; Jose D. Sollano; Qi Zhu; Udom Kachintorn; Abdul Aziz Rani; Ki Baik Hahm; Shin Ichi Takahashi; Takashi Joh; Yoshikazu Kinoshita; Takayuki Matsumoto; Yuji Naito; Koji Takeuchi; Hirokazu Yamagami; Nenny Agustanti; Huifang Xiong; Xi Chen; Eun Jung Jang; Kenji Furuta; Akira Terano

doi:10.1159/000211713

A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007

Tetsuo Arakawa, Yasuhiro Fujiwara, Jose D. Sollano, Qi Zhu, Udom Kachintorn, Abdul Aziz Rani, Ki Baik Hahm, Shin Ichi Takahashi, Takashi Joh, Yoshikazu Kinoshita, Takayuki Matsumoto, Yuji Naito, Koji Takeuchi, Hirokazu Yamagami, Nenny Agustanti, Huifang Xiong, Xi Chen, Eun Jung Jang, Kenji Furuta, Akira Terano

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications. Aim: To examine the current prescription of NSAIDs and comedication to prevent GI complications from NSAIDs within East Asia by means of a questionnaire survey. Methods: Representative members of the Committee of the International Gastrointestinal Consensus Symposium provided a questionnaire to physicians in 6 East Asian countries. Results: A total of 1,568 physicians participated in this survey. Most physicians prescribed nonselective NSAIDs, cyclooxygenase-2 inhibitors (COXIBs) or aspirin for more than 5 patients per week in all countries, with the exception of the prescription of COXIBs in Japan. Of the nonselective NSAIDs, the drug most frequently prescribed as a first choice was loxoprofen (34%), which was mainly prescribed in Japan, followed by diclofenac (30%). The frequency of prescription of comedication with nonselective NSAIDs was higher compared with that for selective COXIBs or aspirin. Physicians in the northern region (China, Japan and Korea) preferred mucoprotective drugs for comedication with NSAIDs or aspirin, while those in southern region (Indonesia, Philippines and Thailand) frequently used proton-pump inhibitors. Conclusion: Among East Asian countries, there are both similarities and differences in the prescription of NSAIDs and of comedication to prevent GI complications.

Original language	English
Pages (from-to)	177-185
Number of pages	9
Journal	Digestion
Volume	79
Issue number	3
DOIs	https://doi.org/10.1159/000211713
Publication status	Published - Apr 2009

Keywords

Aspirin
Cyclooxygenase-2 selective inhibitor
Helicobacter pylori
Mucoprotective drug
Nonsteroidal anti-inflammatory drugs
Proton-pump inhibitor

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10.1159/000211713

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Arakawa, T., Fujiwara, Y., Sollano, J. D., Zhu, Q., Kachintorn, U., Rani, A. A., Hahm, K. B., Takahashi, S. I., Joh, T., Kinoshita, Y., Matsumoto, T., Naito, Y., Takeuchi, K., Yamagami, H., Agustanti, N., Xiong, H., Chen, X., Jang, E. J., Furuta, K., & Terano, A. (2009). A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007. Digestion, 79(3), 177-185. https://doi.org/10.1159/000211713

@article{db332bfecef94f39a220c3c22e37fc6d,

title = "A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007",

abstract = "Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications. Aim: To examine the current prescription of NSAIDs and comedication to prevent GI complications from NSAIDs within East Asia by means of a questionnaire survey. Methods: Representative members of the Committee of the International Gastrointestinal Consensus Symposium provided a questionnaire to physicians in 6 East Asian countries. Results: A total of 1,568 physicians participated in this survey. Most physicians prescribed nonselective NSAIDs, cyclooxygenase-2 inhibitors (COXIBs) or aspirin for more than 5 patients per week in all countries, with the exception of the prescription of COXIBs in Japan. Of the nonselective NSAIDs, the drug most frequently prescribed as a first choice was loxoprofen (34%), which was mainly prescribed in Japan, followed by diclofenac (30%). The frequency of prescription of comedication with nonselective NSAIDs was higher compared with that for selective COXIBs or aspirin. Physicians in the northern region (China, Japan and Korea) preferred mucoprotective drugs for comedication with NSAIDs or aspirin, while those in southern region (Indonesia, Philippines and Thailand) frequently used proton-pump inhibitors. Conclusion: Among East Asian countries, there are both similarities and differences in the prescription of NSAIDs and of comedication to prevent GI complications.",

keywords = "Aspirin, Cyclooxygenase-2 selective inhibitor, Helicobacter pylori, Mucoprotective drug, Nonsteroidal anti-inflammatory drugs, Proton-pump inhibitor",

author = "Tetsuo Arakawa and Yasuhiro Fujiwara and Sollano, {Jose D.} and Qi Zhu and Udom Kachintorn and Rani, {Abdul Aziz} and Hahm, {Ki Baik} and Takahashi, {Shin Ichi} and Takashi Joh and Yoshikazu Kinoshita and Takayuki Matsumoto and Yuji Naito and Koji Takeuchi and Hirokazu Yamagami and Nenny Agustanti and Huifang Xiong and Xi Chen and Jang, {Eun Jung} and Kenji Furuta and Akira Terano",

note = "Funding Information: This work was funded by the Instituto de Salud Carlos III , grant number PI12_01683 to M.A.M., and Comunidad Aut{\'o}noma de Madrid grant number P2010_BMD-2402 . A.B. is supported by CIBERER. We thank Aitor Delmiro for his excellent bioinformatic support, Dr. Elena Garc{\'i}a-Arumi for helping us in designing NGS panel, and Laura Rufi{\'a}n for her technical support. ",

year = "2009",

month = apr,

doi = "10.1159/000211713",

language = "English",

volume = "79",

pages = "177--185",

journal = "Digestion",

issn = "0012-2823",

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Arakawa, T, Fujiwara, Y, Sollano, JD, Zhu, Q, Kachintorn, U, Rani, AA, Hahm, KB, Takahashi, SI, Joh, T, Kinoshita, Y, Matsumoto, T, Naito, Y, Takeuchi, K, Yamagami, H, Agustanti, N, Xiong, H, Chen, X, Jang, EJ, Furuta, K & Terano, A 2009, 'A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007', Digestion, vol. 79, no. 3, pp. 177-185. https://doi.org/10.1159/000211713

TY - JOUR

T1 - A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007

AU - Arakawa, Tetsuo

AU - Fujiwara, Yasuhiro

AU - Sollano, Jose D.

AU - Zhu, Qi

AU - Kachintorn, Udom

AU - Rani, Abdul Aziz

AU - Hahm, Ki Baik

AU - Takahashi, Shin Ichi

AU - Joh, Takashi

AU - Kinoshita, Yoshikazu

AU - Matsumoto, Takayuki

AU - Naito, Yuji

AU - Takeuchi, Koji

AU - Yamagami, Hirokazu

AU - Agustanti, Nenny

AU - Xiong, Huifang

AU - Chen, Xi

AU - Jang, Eun Jung

AU - Furuta, Kenji

AU - Terano, Akira

N1 - Funding Information: This work was funded by the Instituto de Salud Carlos III , grant number PI12_01683 to M.A.M., and Comunidad Autónoma de Madrid grant number P2010_BMD-2402 . A.B. is supported by CIBERER. We thank Aitor Delmiro for his excellent bioinformatic support, Dr. Elena García-Arumi for helping us in designing NGS panel, and Laura Rufián for her technical support.

PY - 2009/4

Y1 - 2009/4

N2 - Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications. Aim: To examine the current prescription of NSAIDs and comedication to prevent GI complications from NSAIDs within East Asia by means of a questionnaire survey. Methods: Representative members of the Committee of the International Gastrointestinal Consensus Symposium provided a questionnaire to physicians in 6 East Asian countries. Results: A total of 1,568 physicians participated in this survey. Most physicians prescribed nonselective NSAIDs, cyclooxygenase-2 inhibitors (COXIBs) or aspirin for more than 5 patients per week in all countries, with the exception of the prescription of COXIBs in Japan. Of the nonselective NSAIDs, the drug most frequently prescribed as a first choice was loxoprofen (34%), which was mainly prescribed in Japan, followed by diclofenac (30%). The frequency of prescription of comedication with nonselective NSAIDs was higher compared with that for selective COXIBs or aspirin. Physicians in the northern region (China, Japan and Korea) preferred mucoprotective drugs for comedication with NSAIDs or aspirin, while those in southern region (Indonesia, Philippines and Thailand) frequently used proton-pump inhibitors. Conclusion: Among East Asian countries, there are both similarities and differences in the prescription of NSAIDs and of comedication to prevent GI complications.

AB - Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications. Aim: To examine the current prescription of NSAIDs and comedication to prevent GI complications from NSAIDs within East Asia by means of a questionnaire survey. Methods: Representative members of the Committee of the International Gastrointestinal Consensus Symposium provided a questionnaire to physicians in 6 East Asian countries. Results: A total of 1,568 physicians participated in this survey. Most physicians prescribed nonselective NSAIDs, cyclooxygenase-2 inhibitors (COXIBs) or aspirin for more than 5 patients per week in all countries, with the exception of the prescription of COXIBs in Japan. Of the nonselective NSAIDs, the drug most frequently prescribed as a first choice was loxoprofen (34%), which was mainly prescribed in Japan, followed by diclofenac (30%). The frequency of prescription of comedication with nonselective NSAIDs was higher compared with that for selective COXIBs or aspirin. Physicians in the northern region (China, Japan and Korea) preferred mucoprotective drugs for comedication with NSAIDs or aspirin, while those in southern region (Indonesia, Philippines and Thailand) frequently used proton-pump inhibitors. Conclusion: Among East Asian countries, there are both similarities and differences in the prescription of NSAIDs and of comedication to prevent GI complications.

KW - Aspirin

KW - Cyclooxygenase-2 selective inhibitor

KW - Helicobacter pylori

KW - Mucoprotective drug

KW - Nonsteroidal anti-inflammatory drugs

KW - Proton-pump inhibitor

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U2 - 10.1159/000211713

DO - 10.1159/000211713

M3 - Article

C2 - 19342858

AN - SCOPUS:63349090510

SN - 0012-2823

VL - 79

SP - 177

EP - 185

JO - Digestion

JF - Digestion

IS - 3

ER -

A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007

Abstract

Keywords

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