A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in east asian countries in 2007

Tetsuo Arakawa, Yasuhiro Fujiwara, Jose D. Sollano, Qi Zhu, Udom Kachintorn, Abdul Aziz Rani, Ki Baik Hahm, Shin Ichi Takahashi, Takashi Joh, Yoshikazu Kinoshita, Takayuki Matsumoto, Yuji Naito, Koji Takeuchi, Hirokazu Yamagami, Nenny Agustanti, Huifang Xiong, Xi Chen, Eun Jung Jang, Kenji Furuta, Akira Terano

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are widely used clinically but increase the risk of gastrointestinal (GI) complications. Aim: To examine the current prescription of NSAIDs and comedication to prevent GI complications from NSAIDs within East Asia by means of a questionnaire survey. Methods: Representative members of the Committee of the International Gastrointestinal Consensus Symposium provided a questionnaire to physicians in 6 East Asian countries. Results: A total of 1,568 physicians participated in this survey. Most physicians prescribed nonselective NSAIDs, cyclooxygenase-2 inhibitors (COXIBs) or aspirin for more than 5 patients per week in all countries, with the exception of the prescription of COXIBs in Japan. Of the nonselective NSAIDs, the drug most frequently prescribed as a first choice was loxoprofen (34%), which was mainly prescribed in Japan, followed by diclofenac (30%). The frequency of prescription of comedication with nonselective NSAIDs was higher compared with that for selective COXIBs or aspirin. Physicians in the northern region (China, Japan and Korea) preferred mucoprotective drugs for comedication with NSAIDs or aspirin, while those in southern region (Indonesia, Philippines and Thailand) frequently used proton-pump inhibitors. Conclusion: Among East Asian countries, there are both similarities and differences in the prescription of NSAIDs and of comedication to prevent GI complications.

Original languageEnglish
Pages (from-to)177-185
Number of pages9
JournalDigestion
Volume79
Issue number3
DOIs
Publication statusPublished - 1 Apr 2009

Keywords

  • Aspirin
  • Cyclooxygenase-2 selective inhibitor
  • Helicobacter pylori
  • Mucoprotective drug
  • Nonsteroidal anti-inflammatory drugs
  • Proton-pump inhibitor

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