A prevalence analysis of Mycoplasma pneumoniae and Chlamydia pneumoniae in Asian adults with community-acquired pneumonia

Hai Hui Huang, Ying Yuan Zhang, Fu Wang, Mediadora Saniel, Marissa Alejandria, Seung Chul Park, You Ning Liu, Po Ren Hsueh, Ahmad M. Aziah, Wing Hong Seto, Cecilia C.L. Ngan, Hadiarto Mangunnegoro, Subharee Suwanjutha, Yun Fong Ngeow, Alsagaff Hood

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5 Citations (Scopus)


Objective: In a previous study, Mycoplasma pneumoniae and Chlamydia pneumoniae were identified as likely etiologic agents in 11.4% and 5.8% respectively among Asian adult patients with community-acquired pneumonia (CAP). This paper further analyzes the clinical and laboratory features of these infections. Methods: Immunocompetent CAP patients of ≥ 16 years old were enrolled at 12 medical centers in Asia. Unified standardized laboratory techniques and interpretation criteria were applied. Results: Varying infection rates were observed among different centers. The presenting symptoms of M. pneumoniae and C. pneumoniae pneumonia were similar and could not be distinguished from those of CAP due to other etiology. There was no gender difference in prevalence for both organisms, but M. pneumoniae was more often found in younger patients (16-44 years) than in those over 45 years of age, while co-morbidity and severe symptoms were more often associated with C. pneumoniae infection. In 88 current M. pneumoniae infections diagnosed by a significant increase in antibody titer, 54.5% were seronegative in the acute-phase serum and, therefore, would have been missed without paired sera diagnosis. For 51 C. pneumoniae current infections, seronegativity was less frequent (21.6%) in the acute-phase serum. Past infection and/or possible carrier by M. pneumoniae and C. pneumoniae were evident in at least 5.7% and 7.9% of patients. Concurrent infections were infrequently seen and not associated with more severe symptoms. Conclusions: In light of significant morbidity and diagnostic difficulties, effective treatment for both M. pneumoniae and C. pneumoniae should be included in the empirical therapy of Asian adults presenting with CAP.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalChinese Journal of Infection and Chemotherapy
Issue number2
Publication statusPublished - 20 Mar 2008


  • Chlamydia pneumonia
  • Chlamydia pneumoniae
  • Community-acquired pneumonia
  • Mycoplasma pneumonia


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