TY - JOUR
T1 - A multicentre surveillance study on the characteristics, bacterial aetiologies and in vitro antibiotic susceptibilities in patients with acute exacerbations of chronic bronchitis
AU - Hui, David S.
AU - Ip, Margaret
AU - Ling, Thomas
AU - Chang, Shan Chwen
AU - Liao, Chun Hsing
AU - Yoo, Chul Gyu
AU - Kim, Deog Kyeom
AU - Yoon, Ho Il
AU - Udompanich, Visit
AU - Mogmeud, Somkid
AU - Muttalif, Razak
AU - Salleh, Azmi M.
AU - Roa, Camilo
AU - Mendoza, Myrna
AU - Fajardo-Ang, Concepcion
AU - Soepandi, Priyanti Zuswayudha
AU - Isbaniah, Fathiyah
AU - Burhan, Erlina
AU - Sudarmono, Pratiwi Pudjilestari
AU - Mangunnegoro, Hadiarto
AU - Liu, Hans H.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Background and objective: Antimicrobial resistance is a global problem and the prevalence is high in many Asian countries. Methods: A prospective observational study of the prevalence of bacterial pathogens and their antimicrobial susceptibilities in patients with acute exacerbations of chronic bronchitis (AECB) was conducted in Indonesia, Philippines, Korea, Thailand, Malaysia, Taiwan andHong Kong fromAugust 2006 to April 2008. The diagnosis of AECB was based on increased cough andworsening of two of following: dyspnoea, increased sputum volume or purulence. Patients who had taken antibiotics within 72 h of presentation were excluded. All bacterial strains were submitted to a central laboratory for re-identification and antimicrobial susceptibility testing to 16 antimicrobial agents according to Clinical and Laboratory Standards Institute. Results: Four hundred and seven isolates were identified among 447 patients of AECB. The most frequent organisms isolated were Klebsiella pneumoniae and associated species (n = 91 + 17), Haemophilus influenzae (n = 71), Pseudomonas aeruginosa (n = 63), Streptococcus pneumoniae (n = 32), Acinetobacter baumannii (n = 22) andMoraxella catarrhalis (n = 21). According to Clinical and Laboratory Standards Institute susceptibility breakpoints, 85.7% and >90% of these pathogens were susceptible to levofloxacin and cefepime respectively.Other options with overall lower susceptibilities include imipenem, ceftazidime, ceftriaxone and amoxicillin/clavulanate. Conclusions: Gram-negative bacteria including Klebsiella spp., P. aeruginosa and Acinetobacter spp. constitute a large proportion of pathogens identified in patients with AECB in some Asian countries. Surveillance on the local prevalence and antibiotic resistance of these organisms is important in guiding appropriate choice of antimicrobials in the management of AECB.
AB - Background and objective: Antimicrobial resistance is a global problem and the prevalence is high in many Asian countries. Methods: A prospective observational study of the prevalence of bacterial pathogens and their antimicrobial susceptibilities in patients with acute exacerbations of chronic bronchitis (AECB) was conducted in Indonesia, Philippines, Korea, Thailand, Malaysia, Taiwan andHong Kong fromAugust 2006 to April 2008. The diagnosis of AECB was based on increased cough andworsening of two of following: dyspnoea, increased sputum volume or purulence. Patients who had taken antibiotics within 72 h of presentation were excluded. All bacterial strains were submitted to a central laboratory for re-identification and antimicrobial susceptibility testing to 16 antimicrobial agents according to Clinical and Laboratory Standards Institute. Results: Four hundred and seven isolates were identified among 447 patients of AECB. The most frequent organisms isolated were Klebsiella pneumoniae and associated species (n = 91 + 17), Haemophilus influenzae (n = 71), Pseudomonas aeruginosa (n = 63), Streptococcus pneumoniae (n = 32), Acinetobacter baumannii (n = 22) andMoraxella catarrhalis (n = 21). According to Clinical and Laboratory Standards Institute susceptibility breakpoints, 85.7% and >90% of these pathogens were susceptible to levofloxacin and cefepime respectively.Other options with overall lower susceptibilities include imipenem, ceftazidime, ceftriaxone and amoxicillin/clavulanate. Conclusions: Gram-negative bacteria including Klebsiella spp., P. aeruginosa and Acinetobacter spp. constitute a large proportion of pathogens identified in patients with AECB in some Asian countries. Surveillance on the local prevalence and antibiotic resistance of these organisms is important in guiding appropriate choice of antimicrobials in the management of AECB.
KW - Acute exacerbation
KW - Antibiotics
KW - Bacteria
KW - Chronic bronchitis
KW - Sputum bacteriology
UR - http://www.scopus.com/inward/record.url?scp=79953268180&partnerID=8YFLogxK
U2 - 10.1111/j.1440-1843.2011.01943.x
DO - 10.1111/j.1440-1843.2011.01943.x
M3 - Article
C2 - 21299688
AN - SCOPUS:79953268180
VL - 16
SP - 532
EP - 539
JO - Respirology
JF - Respirology
SN - 1323-7799
IS - 3
ER -