TY - GEN
T1 - A modification of Johnson score as predictive value of sperm retrieval in non-obstructive azoospermia infertile men
AU - Lestari, Silvia W.
AU - Aditya, Debby
AU - Pratama, Gita
AU - Sumapradja, Kanadi
AU - Margiana, Ria
N1 - Funding Information:
The authors would like to express gratitude to the Hibah Penelitian Dasar Perguruan Tinggi (PDUPT) 2018, contract No: 342/UN2.R3.1/HKP05.00/2018 and No: 01/E/KPT/2018, from Directorate of Research and Community Service (DRPM), at Universitas Indonesia for supporting this study.
Publisher Copyright:
© 2019 Author(s).
PY - 2019/4/9
Y1 - 2019/4/9
N2 - Non obstructive azoospermia (NOA), due to testicular failure, revealed up to 60% of all cases of azoospermia. One of the decisive NOA management is performing testicular sperm extraction (TESE) with success rates approximately 50%, yet a factor for predicting TESE quality is still insufficient. The objective of this work was to assess and develop an alternative outcome predictor of TESE procedure in NOA. To this purpose, a retrospective case series was performed to 31 patients with azoospermia undergone TESE in 2016-2018. Collected data included a clinical history, testicular volume, hormone levels and testicular histology were analyzed following sperm retrieval. The findings resulted in 14 patients had obstructive azoospermia (OA) and 17 patients had NOA. The results showed that all of OA patients had positive sperm retrieval, while NOA patients were 50%. The analyzed data performed that the normal value of testicular size, FSH and the high Johnson score (≥8) were the finest predictor of positive sperm retrieval. In conclusion, the modification of Johnson score may be utilized as a promising predictor of successful or positive surgical sperm retrieval in NOA.
AB - Non obstructive azoospermia (NOA), due to testicular failure, revealed up to 60% of all cases of azoospermia. One of the decisive NOA management is performing testicular sperm extraction (TESE) with success rates approximately 50%, yet a factor for predicting TESE quality is still insufficient. The objective of this work was to assess and develop an alternative outcome predictor of TESE procedure in NOA. To this purpose, a retrospective case series was performed to 31 patients with azoospermia undergone TESE in 2016-2018. Collected data included a clinical history, testicular volume, hormone levels and testicular histology were analyzed following sperm retrieval. The findings resulted in 14 patients had obstructive azoospermia (OA) and 17 patients had NOA. The results showed that all of OA patients had positive sperm retrieval, while NOA patients were 50%. The analyzed data performed that the normal value of testicular size, FSH and the high Johnson score (≥8) were the finest predictor of positive sperm retrieval. In conclusion, the modification of Johnson score may be utilized as a promising predictor of successful or positive surgical sperm retrieval in NOA.
KW - Johnson score
KW - NOA
KW - sperm retrieval
KW - testicular histopathology
UR - http://www.scopus.com/inward/record.url?scp=85064839855&partnerID=8YFLogxK
U2 - 10.1063/1.5096723
DO - 10.1063/1.5096723
M3 - Conference contribution
AN - SCOPUS:85064839855
T3 - AIP Conference Proceedings
BT - 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Wulan, Praswasti P.D.K.
A2 - Gozan, Misri
A2 - Astutiningsih, Sotya
A2 - Ramahdita, Ghiska
A2 - Dhelika, Radon
A2 - Kreshanti, Prasetyanugraheni
PB - American Institute of Physics Inc.
T2 - 3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Y2 - 6 August 2018 through 8 August 2018
ER -