A mini systematic review: Eucheuma cottonii, a red algae, as a radiosensitizer?

Tisa P. Putri, Ida A.T.K. Dewi, Tiara B.M. Permata, Endang Nuryadi, Henry Kodrat, Heri Wibowo, Melva Louisa, Soehartati A. Gondhowiardjo

Research output: Contribution to journalReview articlepeer-review

Abstract

Radiosensitizers assist radiotherapy in providing greater tumor inactivation. Currently there is a search for natural radiosensitizer components which are expected to provide lesser side effects than chemical radiosensitizers. Eucheuma cottonii is a plant with antioxidant and anti-tumor effects. This review aims to search for the potential use of Eucheuma cottonii as a radiosensitizer. This is a mixed review study, where the main component is a systematic review and then followed by a narrative review. This review suggests that Eucheuma cottonii has the potential to become a radiosensitizer, by interfering with the cell cycle control mechanisms and reactivation of p53. Further research is needed to explore the synergistic effect of the combined use of radiotherapy and Eucheuma cottonii.

Original languageEnglish
Pages (from-to)7-15
Number of pages9
JournalTropical Journal of Natural Product Research
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Anti-tumour
  • Eucheuma cottonii
  • Immunomodulator
  • Radiosensitizer

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