A meta-analysis on treatment effects of thiazolidinediones for type 2 diabetes mellitus in Asian populations.

Melva Louisa, Madoka Takeuchi, Masahiro Takeuchi, Nafrialdi, Rianto Setiabudy

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

to assess the effects of thiazolidinediones (pioglitazone and rosiglitazone) in the treatment of T2DM in Asian population. randomized controlled trials of T2DM patients in Asian population that compared pioglitazone or rosiglitazone with other treatments for more than 3 months and reported HbA1c data were included. Analyses for all outcomes were calculated using random effect model. the analyses included 37 studies in approximately 3,000 patients. Thiazolidinediones had beneficial effect on HbA1c (glycosylated hemoglobin/hemoglobin A1c) compared with control (weighted mean difference (WMD) -0.12%; 95% CI [confidence interval], -0.54 to -0.19% for pioglitazone and -0.47%; 95% CI, -0.89 to -0.40% for rosiglitazone). Overall, TZDs showed significant benefit on glycemic outcomes measured by HbA1c as main surrogate outcome compared with previous glycemic control but not with other anti-diabetics. thiazolidinediones treatment resulted in favorable effects on glycemic control in Asian patients with T2DM. Long-term efficacy and safety data of TZD could not yet be confirmed due to the lack of randomized studies with patient-oriented outcomes.

Original languageEnglish
Pages (from-to)39-52
Number of pages14
JournalActa medica Indonesiana
Volume43
Issue number1
Publication statusPublished - 1 Jan 2011

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