A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population

Clarissa Ganda; Sibylle G. Schwab; Nurmiati Amir; null Heriani; Irman Irmansyah; Aaaa Kusumawardhani; Martina W Nasrun; Ika Widyawati; Wolfgang Maier; Dieter B. Wildenauer

doi:10.1017/S1461145709990356

A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population

Clarissa Ganda, Sibylle G. Schwab, Nurmiati Amir, Heriani, Irman Irmansyah, Aaaa Kusumawardhani, Martina W Nasrun, Ika Widyawati, Wolfgang Maier, Dieter B. Wildenauer

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

We previously reported genome-wide significant linkage to chromosome 3p in a sib-pair family sample from Indonesia. A promising candidate gene within the linked region is the metabotropic glutamate receptor subtype 7 (GRM7), involved in glutamatergic neurotransmission. We genotyped 18 single nucleotide polymorphisms in GRM7 in the sample of 124 Indonesian sib-pair families that had provided the significant linkage finding. Transmission disequilibrium analysis revealed nominally significant transmission distortion of rs17031835 in intron 1 of GRM7 (p=0.004, before correction for multiple testing), along with haplotypes containing rs17031835. No other single marker was found to be significantly associated with schizophrenia in our sample. The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted.

Original language	English
Pages (from-to)	1283-1289
Number of pages	7
Journal	International Journal of Neuropsychopharmacology
Volume	12
Issue number	9
DOIs	https://doi.org/10.1017/S1461145709990356
Publication status	Published - Oct 2009

Keywords

Family-based association
GRM7
Indonesia
schizophrenia

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Ganda, C., Schwab, S. G., Amir, N., Heriani, Irmansyah, I., Kusumawardhani, A., Nasrun, M. W., Widyawati, I., Maier, W., & Wildenauer, D. B. (2009). A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population. International Journal of Neuropsychopharmacology, 12(9), 1283-1289. https://doi.org/10.1017/S1461145709990356

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abstract = "We previously reported genome-wide significant linkage to chromosome 3p in a sib-pair family sample from Indonesia. A promising candidate gene within the linked region is the metabotropic glutamate receptor subtype 7 (GRM7), involved in glutamatergic neurotransmission. We genotyped 18 single nucleotide polymorphisms in GRM7 in the sample of 124 Indonesian sib-pair families that had provided the significant linkage finding. Transmission disequilibrium analysis revealed nominally significant transmission distortion of rs17031835 in intron 1 of GRM7 (p=0.004, before correction for multiple testing), along with haplotypes containing rs17031835. No other single marker was found to be significantly associated with schizophrenia in our sample. The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted.",

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AU - Amir, Nurmiati

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AU - Irmansyah, Irman

AU - Kusumawardhani, Aaaa

AU - Nasrun, Martina W

AU - Widyawati, Ika

AU - Maier, Wolfgang

AU - Wildenauer, Dieter B.

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AB - We previously reported genome-wide significant linkage to chromosome 3p in a sib-pair family sample from Indonesia. A promising candidate gene within the linked region is the metabotropic glutamate receptor subtype 7 (GRM7), involved in glutamatergic neurotransmission. We genotyped 18 single nucleotide polymorphisms in GRM7 in the sample of 124 Indonesian sib-pair families that had provided the significant linkage finding. Transmission disequilibrium analysis revealed nominally significant transmission distortion of rs17031835 in intron 1 of GRM7 (p=0.004, before correction for multiple testing), along with haplotypes containing rs17031835. No other single marker was found to be significantly associated with schizophrenia in our sample. The results from our study provide support for the idea that glutamatergic neurotransmission and specifically the GRM7 gene might be relevant to the development of schizophrenia. Further studies supporting this finding are warranted.

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A family-based association study of DNA sequence variants in GRM7 with schizophrenia in an Indonesian population

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