A facile electrochemical sensor based on a composite of electrochemically reduced graphene oxide and a PEDOT:PSS modified glassy carbon electrode for uric acid detection

Budi R. Putra, Ulfiatun Nisa, Rudi Heryanto, Eti Rohaeti, Munawar Khalil, Arini Izzataddini, Wulan T. Wahyuni

Research output: Contribution to journalArticlepeer-review

Abstract

A glassy carbon electrode modified with electrochemically reduced graphene oxide (ErGO) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) was developed for uric acid determination with dopamine as interference in artificial saliva. The electrochemical performance of the fabricated electrode was studied using both techniques of cyclic voltammetry (CV) and differential pulse voltammetry (DPV), under optimized conditions. Using DPV, the sensor based on ErGO/PEDOT:PSS modified GCE displayed a linear relationship in the concentration ranges of 10-100 µM for uric acid. This uric acid sensor exhibited a high sensitivity with detection limits of 1.08 µM and quantitation limit of 3.61 µM. This sensor also showed good reproducibility for uric acid detection in artificial saliva in 5 consecutive days of measurements. This device was successfully used to analyze uric acid in artificial saliva as well as in a human saliva sample using the standard addition method.

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry
Volume38
Issue number1
DOIs
Publication statusPublished - 1 Jan 2022

Keywords

  • Artificial saliva
  • Dopamine
  • Electrochemically reduced graphene oxide
  • PEDOT:PSS
  • Uric acid

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