A Double Blind Randomized Trial Showing Probiotics to be Ineffective in Acute Diarrhea in Indonesian Children

Badriul Hegar Syarif, Made Indra Waspada, Hartono Gunardi, Yvan Vandenplas

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Objective: To investigate the efficacy of probiotics added to oral rehydration solution and zinc in the treatment of acute infectious diarrhea in Indonesian children. Methods: A prospective randomized double blind placebo-controlled trial was performed to test the efficacy of a probiotic food supplement in 112 children in the Kenari subdistrict, central Jakarta, aged 6–36 mo with acute infectious diarrhea and moderate dehydration. The supplemented group was given standard therapy (oral rehydration solution and zinc) and the probiotic strains Lactobacillus (L.) rhamnosus R0011 1.9 × 109 colony forming units (cfu) and L. acidophilus R0052 0.1 × 109 cfu/d for 7 d, while the control group was given standard therapy and placebo. Results: Median duration of diarrhea was 68.5 h (range 13–165) in the supplemented and 61.5 h (range 21–166) in the control group (P = 0.596). Median daily frequency of defecation until diarrhea stopped was 5.0 in the supplemented vs. 5.5 in the control group (P = 0.795). Conclusions: This probiotic food supplement tested did not reduce the duration of acute infectious diarrhea as compared to oral rehydration and zinc.

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalIndian Journal of Pediatrics
Volume82
Issue number5
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • Acute diarrhea
  • Acute gastroenteritis
  • Lactobacillus
  • Oral rehydration (solution)
  • Probiotic
  • Zinc

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