A double-blind placebo-controlled randomized trial on probiotics in small bowel bacterial overgrowth in children treated with omeprazole

Badriul Hegar Syarif, Esther I. Hutapea, Najib Advani, Yvan Vandenplas

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Objective To evaluate the incidence of small bowel bacterial overgrowth (SBBO) in children treated with omeprazole, and to test whether probiotics influence the incidence. Methods A double-blinded, placebo-controlled trial was performed in 70 children treated orally during four weeks with 20 mg omeprazole per day. Lactobacillus rhamnosus R0011 (1.9 × 109 cfu) and Lactobacillus acidophillus R0052 (0.1 × 109 cfu) were simultaneously given daily to 36 subjects (probiotic group), while 34 subjects received placebo (placebo group). The diagnosis of SBBO was based on the development of suggestive symptoms, in combination with a positive glucose breath test. Results After one month of proton pump inhibitor (PPI) treatment, 30% (21/70) had a positive breath test suggesting SBBO; of these 62% were symptomatic. Five children developed SBBO-like symptoms, but had a negative breath test; and 44 (63%) were symptom free and had a negative breath test. There was no difference in the incidence of positive breath tests in the probiotic versus the placebo group (33% vs 26.5%; p = 0.13). Conclusions Since symptoms suggesting SBBO developed in 26% of PPI-treated children, and since the glucose breath test was abnormal in 72% of these, this side-effect should be more frequently considered. The probiotic tested did not decrease the risk to develop SBBO.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalJornal de Pediatria
Volume89
Issue number4
DOIs
Publication statusPublished - 1 Jul 2013

Keywords

  • (Hydrogen) breath test
  • Diarrhea
  • Flatulence
  • Omeprazole
  • Probiotic
  • Proton pump inhibitor
  • Small bowel bacterial overgrowth

Fingerprint Dive into the research topics of 'A double-blind placebo-controlled randomized trial on probiotics in small bowel bacterial overgrowth in children treated with omeprazole'. Together they form a unique fingerprint.

Cite this