TY - JOUR
T1 - 2-[(2,6-Dimethylmorpholin-4-yl)methyl]-4-[(E)-2-{3- [(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4- hydroxy-5-methoxyphenyl}ethenyl]-1H-pyrazol-5- yl}ethenyl]-6-methoxyphenol
AU - Untung, Joko
AU - Iskandarsyah, Iskandarsyah
AU - Hayun, Hayun
N1 - Funding Information:
We thank the Directorate of Research and Community Services, Universitas Indonesia, Depok, Indonesia, for the financial support of this research. We are also thankful to the Research Center for Chemistry, the Indonesian Institute of Sciences, Serpong, Indonesia, and to the Chemistry Study Program, Faculty of Natural Sciences, Bandung Institute of Technology (ITB), Bandung, Indonesia, for recording spectral data.
Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2017/9
Y1 - 2017/9
N2 - A novel di-Mannich derivative of curcumin pyrazole, 2-[(2,6-dimethyl morpholin-4- yl)methyl]-4-[(E)-2-{3-[(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4-hydroxy-5-methoxyphenyl} ethenyl]-1H-pyrazol-5-yl}ethenyl]-6-methoxyphenol (2), has been synthesized through a Mannich reaction of curcumin pyrazole (1), formaldehyde, and 2,6-dimethylmorpholine. The structure of the synthesized compound was confirmed on the basis of FTIR, 1H-NMR, 13C-NMR, 2D Heteronuclear Single-Quantum Correlation (HSQC) and 2D Heteronuclear Multiple Bond Correlation (HMBC), and mass spectral data. The water solubility was evaluated and the result showed that compound 2 was three times more soluble than that of curcumin pyrazole (1) and curcumin.
AB - A novel di-Mannich derivative of curcumin pyrazole, 2-[(2,6-dimethyl morpholin-4- yl)methyl]-4-[(E)-2-{3-[(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4-hydroxy-5-methoxyphenyl} ethenyl]-1H-pyrazol-5-yl}ethenyl]-6-methoxyphenol (2), has been synthesized through a Mannich reaction of curcumin pyrazole (1), formaldehyde, and 2,6-dimethylmorpholine. The structure of the synthesized compound was confirmed on the basis of FTIR, 1H-NMR, 13C-NMR, 2D Heteronuclear Single-Quantum Correlation (HSQC) and 2D Heteronuclear Multiple Bond Correlation (HMBC), and mass spectral data. The water solubility was evaluated and the result showed that compound 2 was three times more soluble than that of curcumin pyrazole (1) and curcumin.
KW - 2,6-dimethylmorpholine
KW - Curcumin pyrazole
KW - Di-mannich derivative
KW - Water solubility
UR - http://www.scopus.com/inward/record.url?scp=85027057498&partnerID=8YFLogxK
U2 - 10.3390/M949
DO - 10.3390/M949
M3 - Article
AN - SCOPUS:85027057498
SN - 1422-8599
VL - 2017
JO - MolBank
JF - MolBank
IS - 3
M1 - M949
ER -