2-[(2,6-Dimethylmorpholin-4-yl)methyl]-4-[(E)-2-{3- [(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4- hydroxy-5-methoxyphenyl}ethenyl]-1H-pyrazol-5- yl}ethenyl]-6-methoxyphenol

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A novel di-Mannich derivative of curcumin pyrazole, 2-[(2,6-dimethyl morpholin-4- yl)methyl]-4-[(E)-2-{3-[(E)-2-{3-[(2,6-dimethylmorpholin-4-yl)methyl]-4-hydroxy-5-methoxyphenyl} ethenyl]-1H-pyrazol-5-yl}ethenyl]-6-methoxyphenol (2), has been synthesized through a Mannich reaction of curcumin pyrazole (1), formaldehyde, and 2,6-dimethylmorpholine. The structure of the synthesized compound was confirmed on the basis of FTIR, 1H-NMR, 13C-NMR, 2D Heteronuclear Single-Quantum Correlation (HSQC) and 2D Heteronuclear Multiple Bond Correlation (HMBC), and mass spectral data. The water solubility was evaluated and the result showed that compound 2 was three times more soluble than that of curcumin pyrazole (1) and curcumin.

Original languageEnglish
Article numberM949
Issue number3
Publication statusPublished - Sept 2017


  • 2,6-dimethylmorpholine
  • Curcumin pyrazole
  • Di-mannich derivative
  • Water solubility


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