Bioanalysis in Biological Matrices research cluster integrates analytical chemistry, pharmacokinetics, and pharmacology approaches to study small molecules/macromolecules in living organisms to support diagnosis and therapy in clinical setting. Research in this cluster focuses on the qualitative and quantitative analysis of analytes/metabolites/biomarkers in specific biological matrices such as blood, plasma, serum, urine, saliva, and other biological matrices, for implementation in pharmacokinetic studies, bioavailability/bioequivalence studies, therapeutic drug monitoring (TDM), pharmacogenomic studies, DNA adduct analysis (carcinogenesis), metabolomic studies, and related research. The scope of the research includes the development of bioanalytical methods, method validation based on international guidelines (EMA, FDA), and the application of these bioanalytical methods in the aforementioned studies.